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醋酸去氢表雄酮 |
| CAS No.: |
853-23-6 |
| 分子式： |
C21H30O3 |
| 分子量： |
330.47 |
| 备注： |
中文名称醋酸去氢表雄酮中文同义词醋酸去氢表雄酮,去氢表雄酮醋酸酯;3-乙酸脱氢异雄甾酮;3-乙酸脱氢异雄(甾)酮;反式-醋酸脱氢雄(甾)酮;醋酸去氢表雄酮(甾体);醋酸去氢表雄酮英文名称;醋酸去氢素雄酮;3-醋酸去氢表雄酮英文名称Dehydroepiandrosteroneacetate英文同义词3B-ACETOXY-5-ANDROSTEN-17-ONE;3BETA-ACETOXY-5-ANDROSTEN-17-ONE;3BETA-ACETOXY-5-ANDROSTEN-17-ONEACETATE;3B-HYDROXYANDROST-5-EN-17-ONEACETATE;3-(ACETYLOXY)ANDROST-5-ENE-17-ONE;5-ANDROSTEN-3-BETA-ACETOXY-3-ONE;5-ANDROSTEN-3BETA-OL-17-ONE3-ACETATE;5-ANDROSTEN-3-BETA-OL-17-ONEACETATECAS号853-23-6分子式C21H30O3分子量330.47EINECS号212-714-1相关类别手性砌块;小分子抑制剂，天然产物;小分子抑制剂;医药原料;中间体;维生素与氨基酸;原料;激素甾体;不对称合成;其他化学试剂;原料药;医药中间体;PharmaceuticalIntermediates;Steroids;17-Ketosteroids;Biochemistry;Hydroxyketosteroids;Chemistry;Intermediates&FineChemicals;Metabolites&Impurities;Pharmaceuticals;API;Inhibitors;化合物;甾体激素原料中间体;合成材料;医用原料;男性保健原料;药物杂质及中间体;医药原料和中间体;化工中间体;原料药;有机化工原料;工业化;对照品Mol文件853-23-6.mol结构式醋酸去氢表雄酮性质熔点168-170°C(lit.)沸点407.89°C(roughestimate)密度1.0998(roughestimate)蒸气压0Paat20℃折射率1.5192(estimate)储存条件Refrigerator溶解度可溶于氯仿、DMSO（微溶）、甲醇（微溶）形态固体颜色白色至类白色旋光性(opticalactivity)[α]20/D+2.4°,c=2inethanol水溶解性11.5mg/L(temperaturenotstated)InChIInChI=1/C21H30O3/c1-13(22)24-15-8-10-20(2)14(12-15)4-5-16-17-6-7-19(23)21(17,3Chemicalbook)11-9-18(16)20/h4,15-18H,5-12H2,1-3H3/t15-,16-,17-,18-,20-,21-/s3InChIKeyNCMZQTLCXHGLOK-KJBVPOJVSA-NSMILESC[C@]12CC[C@H](OC(=O)C)CC1=CC[C@@]1([H])[C@]3([H])CCC(=O)[C@@]3(C)CC[C@]21[H]|&1:1,4,13,15,21,25,r|LogP5.1at20℃CAS数据库853-23-6醋酸去氢表雄酮用途与合成方法生物活性Dehydroepiandrosterone3-acetate是雄性激素/雌性激素的前体物质，能够调节脊椎动物的攻击性行为。体内研究Dehydroisoandrosteroneimplantsincreasesaggressioninalaboratory-basedsimulatedterritorialintrusion.BrainsofDehydroisoandrosterone-implantedbirdsshowhigheraromatasemRNAexpressioninthepreopticarea(POA)andhigherandrogenreceptormRNAexpressionintheperiventricularnucleusofthemedialstriatum(pvMSt)andventromedialnucleusofthehypothalamus(VMH).TheDehydroisoandrosterone-inducedincreasesinaromataseexpressioninthePOAandandrogenreceptorexpressioninthepvMStareconsistentwithpreviouslyreportedseasonalincreasesinthesemarkersassociatedwithnaturallyelevatedDehydroisoandrosteronelevels.Dehydroisoandrosteronesupplementation(10.2mg/kg)alonesignificantlyincreasesmicebodyweight(BW),muscleweight,testosteronelevel,andglycogencontents(liverandmuscle)whencomparedwithSCgroup.用途用于合成甾体激素药物用途醋酸去氢表雄酮是合成各种激素、计划生育用品等甾体激素类药物的重要中间体，由它可合成睾丸素、甲基睾丸素、雌二醇、雌三醇 |
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