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吡啶酮乙醇胺盐 |
| CAS No.: |
68890-66-4 |
| 分子式： |
C14H23NO2.C2H7NO;C16H30N2O3 |
| 分子量： |
298.42 |
| 备注： |
中文名称吡啶酮乙醇胺盐中文同义词去屑剂;吡罗克酮乙醇铵;1-羟基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺复合盐;吡罗克酮乙醇胺盐;吡啶酮乙醇胺盐(去屑剂OCTO);吡啶酮乙醇胺盐;羟吡酮;罗酮奥拉明英文名称Piroctoneolamine英文同义词2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1);4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon;octopiroxolamine;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1);Hydroxylpyrazoleketones;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridonmonoethanolamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl);-onecompoundwith2-aminoethanol(1:1)CAS号68890-66-4分子式C16H30N2O3分子量298.43EINECS号272-574-2相关类别吡啶;乙醇铵盐;分析标准品;化妆品日化原料;化学试剂;医用原料;化工原料;化妆品原料;化工中间体;有机原料;吡啶酮乙醇胺盐;精细化工;食品添加剂;杀菌剂类;小分子抑制剂;医药原料;农业和环境标准品;酮;日化原料/化妆品;化工原料-1;化工;医用原料;化工中间体;原料;日化原料;化工原料-1827181813;昆虫信息素;材料中间体;抗菌防腐;精细化工品;化妆品类;医药化学品;有机化工原料;去屑剂;化工原料;化妆品日化原料;有机中间体;防腐剂;定制;OLEDmaterials,pharmchemical,electronic;ARAMINE;bacteriostaticandfungistatic;PP;68890-66-4;头发护理;对照品Mol文件68890-66-4.mol结构式吡啶酮乙醇胺盐性质熔点134.0to138.0°C沸点135-235℃[at101325Pa]密度1.1[at20℃]蒸气压0-0Paat20-25℃储存条件Inertatmosphere,2-8°C溶解度可溶于氯仿（轻微，超声处理），甲醇（轻微）酸度系数(pKa)5.9-7.4[at20℃]形态固体颜色白色至类白色水溶解性400-50000mg/Lat20-25℃Merck14,7502InChIInChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2InChIKeyBTSZTGGZJQFALU-UHFFFAOYSA-NSMILESC(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)CLoChemicalbookgP1.05-3.86at20-25℃CAS数据库68890-66-4(CASDataBaseReference)吡啶酮乙醇胺盐用途与合成方法简介吡罗克酮乙醇胺盐独特的性能主要表现在：1.去屑止痒效果优于同类产品。2.溶解性能、复配性能优良，与化妆品原料混合不会发生沉淀或分层现象。3.去屑机理独特，刺激性极低，不会引起脱发、断发，安全性优于同类去屑止痒产品。用途羟吡酮是一种高效、无毒无刺激的去屑剂，可以广泛使用于去屑香波、养发液和护发素等洗护类化妆品中。生物活性吡啶酮乙醇胺盐是一种吡啶衍生物。具有杀真菌作用。靶点Antifungal体外研究Piroctoneolamine,theethanolaminesaltofthehydroxamicacidderivativePiroctone,isahydroxypyridoneanti-mycoticagent.Piroctoneolaminepenetratesthecellmembraneandformscomplexeswithironions,inhibitingenergymetabolisminmitochondria.Piroctoneolamine(PO)isanethanolaminesaltofthehydroxamicacidderivativePiroctone.AllCandidastrainsshowlowminimuminhibitoryconcentrations(MICs)forPiroctoneolamine(0.125-0.5μg/mL)andAmphotericinB(AMB)(0.03-1μg/mL).体内研究ThisworkaimedtoevaluatetheantifungalactivityofPiroctoneolamineinthetreatmentofintra-abdominalcandidiasisinanexperimentalmodelusingSwissmice.ThetreatmentwithPiroctoneolamine(0.5mg/kg)isperformed72hafterinfectionbyintraperitonealadministration.Forcomparison,agroupofanimals(n=6)istreatedwithAmphotericinB(0.5mg/kg).Themycologicaldiagnosisismadebycollectingtheliver,spleenandkidneys.DataregardingthefungalgrowthandmortalityareanalyzedstatisticallybyStudent’sttestandanalysisofvariance,withlevelofsignificancesetatP<0.05.Thedifferenceinfungalgrowthscoringbetweenthecontrolgroupandthetreatmentgroups(PiroctoneolamineandAmphotericinB)isstatisticallysignificant(P<0.05). |
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