湖北蝶化新材料科技有限公司

5714-73-8

C15H21N5O3

319.36

中文名称马尿酸乌洛托品中文同义词马尿酸乌洛托品;环六亚甲基四胺N-苯甲酰甘氨酸盐;马尿酸孟德立胺;马尿酸乌洛托USP标准品;1,3,5,7-四氮杂金刚烷苯甲酰基甘氨酸盐;乌洛托品马尿酸盐;马尿酸亚甲胺英文名称Methenaminehippurate英文同义词1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane,compd.withN-benzoylglycine(1:1);N-benzoylglycine,compoundwith1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane(1:1);METHENAMINEHIPPURATE,USP;N-Benzoylglycine1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane(1:1);Hexamethylentetraminemonohippurate;Methenaminehippurate;Methinaminehippurate(USP);glycine,n-benzoyl-,compd.with1,3,5,7-tetraazatricyclo(3.3.1.1(sup3,7))deCAS号5714-73-8分子式C15H21N5O3分子量319.37EINECS号227-206-5相关类别其他原料药;有机化工原料;Heterocycles;Intermediates&FineChemicals;PharmaceuticalsMol文件5714-73-8.mol结构式马尿酸乌洛托品性质熔点89-95°C储存条件InertaChemicalbooktmosphere,RoomTemperature溶解度可溶于DMSO（少许）、甲醇（少许）形态固体颜色白色至类白色马尿酸乌洛托品用途与合成方法用途马尿酸乌洛托品作为防治尿路感染的抗生素替代药物具有深远意义，它能降低抗生素使用，减少细菌耐药。生物活性MethenamineHippurate是methenamine的马草酸盐形式，是一种前药和惰性弱碱，在酸性尿液中会水解成甲醛。MethenamineHippurate是Hiprex药物的成分，具有抗菌活性。体外研究Methenaminehippurateisaurinaryantibacterialagentwhichreleasesformaldehydeandisexcretedintheurine.MethenaminehippuratehasademonstrableactivityinvitroatpH5to6againstEscherichiacoli,Staphylococcusaureus,Aerobacteraeroaenes,PseudomonasaeruginosaandProteusvulgaris,andawiderangeofactionagainstKlebsiellapneumoniae,Ps.aeruginosa,E.coli,Staph.aureusandStreptococcushaemolyticatpHof7.4.ThisactionismoreeffectivethanthatofMethenaminealone,ofHippuricacidaloneorofSulphadiazine.