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2,4,6-三羟基苯乙酮 |
| CAS No.: |
480-66-0 |
| 分子式： |
C8H8O4.H2O |
| 分子量： |
186.16 |
| 备注： |
中文名称2,4,6-三羟基苯乙酮中文同义词2,4,6-三羟基苯乙酮，水合;2’,4’,6’-三羟基苯乙酮一水合物;2’,4’,6’-三羟基苯乙酮水合物;2,4,6-三羟基苯乙酮;6-三羟基苯乙酮;2,4,6-三羟基苯乙酮一水;苯乙酮,2’,4’,6’-三羟基-;三羟基苯乙酮一水合物英文名称2’,4’,6’-Trihydroxyacetophenonemonohydrate英文同义词2’,4’,6’-Trihydroxyacetophenonemonohydrate;2-Acetylphloroglucinolhydrate;Phloroacetophenonemonohydrate;THAP;2’,4’,6’-Trihydroxyacetophenone(monohydrate/anhydrous);2’,4’,6’-Trihydroxyacetophenonehydrate,98+%;1-(2,4,6-TRIHYDROXYPHENYL)-ETHANONE;2’,4’,6’-TRIHYDROXYACETOPHENONECAS号480-66-0分子式C8H8O4分子量168.15EINECS号207-556-5相关类别微生物代谢物;通用试剂;医药中间体;有机砌块;中间体;其它有机金属化合物;酮;小分子抑制剂;小分子抑制剂，天然产物;醇类及衍生物;羰基化合物;有机化工原料;活性分子;AlcoholsandDerivatives;CarbonylCompounds;AromaticAcetophenones&Derivatives(substituted);AnalyticalChemistry;MassSpectrometry;MatrixMaterials(MALDI-TOF-MS);Aromatics;Intermediates&FineChemicals;Pharmaceuticals;BuildingBlocks;C7toC8;ChemicalSynthesis;Ketones;OrganicBuildingBlocks;Inhibitors;其它酚类;医药原料;化工原料;合成材料中间体;中间体-有机中间体;化学试剂;对照品Mol文件480-66-0.mol结构式2,4,6-三羟基苯乙酮性质熔点219-221°C(lit.)沸点257.07°C(roughestimate)密度1.3037(roughestimate)折射率1.5090(estimate)储存条件Storebelow+3Chemicalbook0°C.溶解度可溶于DMSO（少量）、乙醇（少量）、甲醇（少量）、水（非常少量，酸度系数(pKa)7.76±0.23(Predicted)形态粉末颜色浅黄色水溶解性Solubleinwater.BRN1911197稳定性在建议的储存条件下稳定。LogP1.472(est)CAS数据库480-66-0(CASDataBaseReference)NIST化学物质信息Ethanone,1-(2,4,6-trihydroxyphenyl)-(480-66-0)EPA化学物质信息Ethanone,1-(2,4,6-trihydroxyphenyl)-(480-66-0)2,4,6-三羟基苯乙酮用途与合成方法生物活性Phloracetophenone(2,4,6-trihydroxyacetophenone)是多叶姜黄(CurcumacomosaRoxb)中苯乙酮糖苷的糖苷配基部分，具有降低胆固醇作用，能够增强胆固醇7α-羟化酶(CYP7A1)的活性；Phloracetophenone通过Mrp2刺激胆汁分泌。靶点Cholesterol7α-hydroxylase,Mrp2体外研究Phloracetophenone(2,4,6-trihydroxyacetophenone)isacholesterol-loweringagent,enhancescholesterol7α-hydroxylase(CYP7A1)activity,andelevatesCYP7A1mRNAlevel.Phloracetophenone(1,2,and4μmol/min)immediatelyanddose-dependentlyincreasesbileacid-independentbileflowintheisolatedperfusedratliver.体内研究Phloracetophenone(2,4,6-trihydroxyacetophenone;125or250μmol/kg,intraduodenalinjection)showscholereticactivityrequiringmultidrugresistanceprotein-2(Mrp2)inrats.Phloracetophenone(40μmol/min)partiallypreventstheE2-17Ginducedcholestasis.化学性质微黄色结晶。熔点217-219℃。用途本品用于有机合成、医药中间体和合成新型抗氧剂黄烷酮等。 |
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