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2,4-二氯嘧啶 |
CAS No.: |
3934-20-1 |
分子式: |
C4H2Cl2N2 |
分子量: |
148.98 |
备注: |
中文名称2,4-二氯嘧啶中文同义词2,4-二氯嘧啶(97%);2,4-二氯嘧啶,98+%;2,4-二氯嘧啶盐酸盐;2,4-二氯嘧啶;2,6-二氯嘧啶;嘧啶,2,4-二氯-;2,4-二氯嘧;2,4-二氯嘧啶1G英文名称2,4-Dichloropyrimidine英文同义词2,4-DICHLOROPYRIMIDINE;2,6-DICHLOROPYRIMIDINE;2-4-DICHLOROPYRIMIDINECRYSTALLINE;AKOS91058;2,4-dichloro-pyrimidin;2,4-Dichlorpyrimidin;Pyrimidine,2,4-dichloro-;2,4-DichloropyrimidinePazopanibCAS号3934-20-1分子式C4H2Cl2N2分子量148.98EINECS号223-508-6相关类别嘧啶系列;帕唑帕尼中间体;嘧啶;杂环砌块;嘧啶类;杂环化合物;有机化工原料;有机原料;医药中间体;中间体;原料药中间体;通用试剂;帕唑帕尼Pazopanib;PyrimidineSeries;Pyridines,Pyrimidines,PurinesandPteredines;Halides;Pyrazines,Pyrimidines&Pyridazines;HeterocyclicCompounds;BuildingBlocks;AromaticsCompounds;Pyrimidines;Aromatics;Heterocycles;Pyrazines,Pyrimidines&Pyridazines;BuildingBlocks;HalogenatedHeterocycles;HeterocyclicBuildingBlocks;PyrimidinesHeterocyclicBuildingBlocks;助剂中间体;有机化学;原料;化工原Chemicalbook料;有机化学;医药原料;吡啶类;无机物;化工材料;供应产品;医药原料中间体;PYRIMIDINE;Heterocycle-Pyrimidineseries;bc0001Mol文件3934-20-1.mol结构式2,4-二氯嘧啶性质熔点57-61°C(lit.)沸点101°C/23mmHg(lit.)密度1.6445(roughestimate)折射率1.6300(estimate)闪点101°C/23mm储存条件Keepindarkplace,Sealedindry,RoomTemperature溶解度可溶于氯仿(少许)、乙酸乙酯(少许)、甲醇(少许)酸度系数(pKa)-2.84±0.20(Predicted)形态粉末、晶体或块状颜色白色到黄色到米色或浅灰色水溶解性Solubleinwater(partly),methanol,chloroform,andethylacetate.敏感性MoistureSensitiveBRN110911InChIKeyBTTNYQZNBZNDOR-UHFFFAOYSA-NCAS数据库3934-20-1(CASDataBaseReference)NIST化学物质信息Pyrimidine,2,4-dichloro-(3934-20-1)EPA化学物质信息Pyrimidine,2,4-dichloro-(3934-20-1)2,4-二氯嘧啶用途与合成方法化学性质熔点58-61℃,沸点101℃(3.07kPa)。用途用于生产药物阿糖胞甙盐酸盐。用途用于药物化学合成中的砌块;用于Suzuki偶联、烷基化等反应的砌块生产方法由尿嘧啶氯化而得。将尿嘧啶、三氯氧磷和二甲苯胺加入反应锅,加热至130℃,回流约45min,稍冷却,放放碎冰中,即析出紫色固体,趁热未溶时过滤,用冰水洗涤,真空干燥,得类紫色粗品,用石油醚(沸程60-90℃)脱色、重结晶,得2,4-二氯嘧啶。 |
结构式: |
![](https://www.hxchem.net/dimages/3934-20-1.gif) |
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