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盐酸益母草碱 |
| CAS No.: |
24697-74-3 |
| 分子式： |
C14H21O5N3.HCl.H2O |
| 分子量： |
365.81 |
| 备注： |
中文名称盐酸益母草碱中文同义词益母草碱盐酸盐,益母草碱;盐酸益母草碱(益母草碱盐酸盐,益母草碱);LEONURINEHYDROCHLORIDE盐酸益母草碱;盐酸益母草碱(3,5-二甲氧基-4-羟基-苯甲酸(4-胍基)-1-丁酯一水合物盐酸盐);盐酸益母草碱;3,5-二甲氧基-4-羟基-苯甲酸(4-胍基)-1-丁酯一水合物盐酸盐;益母草碱盐酸盐;盐酸益母草碱(标准品)英文名称Leonurinehydrochloride英文同义词Leonurine4-Guanidino-1-butanolsyringate;SCM-198;leonurinehydrochloride;4-Guanidino-1-butanolsyringate;4-(diaminomethylideneamino)butyl4-hydroxy-3,5-dimethoxy-benzoatehydrochloride;Leonurine;LEONURINEHCL;4-Hydroxy-3,5-dimethoxybenzoicacid4-guanidinobutylesterCAS号24697-74-3分子式C14H21N3O5分子量311.33EINECS号683-174-6植物来源益母草相关类别中草药成分;中药对照品;标准品;对照品,标准品;植物提取物;合成;对照品;植提标准品;医药原料药;标准品-对照品;标准品-中药标准品;对照品-中药对照品;生物碱;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;标准品-中药标准品;标准品，对照品;原料;医药化工类Mol文件24697-74-3.mol结构式盐酸益母草碱性质熔点238°C沸点496.7±55.0°C(Predicted)密度1.29±0.1g/cm3(Predicted)储存条件Keepindarkplace,Inertatmosphere,2-8°C溶解度DMSO：可溶，2mg/mL，澄清（加热）酸度系数(pKa)8.26±0.25(Predicted)形态粉末颜色白色至米色稳定性可在-20°C下的DMSO溶液保存长达1个月。InChIKeyWNGSUWLDMZFYNZ-UHFFFAOYSA-N盐酸益母草碱用途与合成方法生物活性Leonurine是从Herbaleonuri中分离到的生物碱，具有抗氧化、抗炎活性。体外研究Leonurine(0,5,10,20,40,80µM)causesdiminutioninlipidaccumulation,cellularcholesterolcontent,includingtotalcholesterol(TC),freecholesterol(FC)andcholesterylester(CE),andincreaseinapoA-I-orHDL-meChemicalbookdiatedcholesteroleffluxaftertreatmentfor24h.Leonurinealsosignificantlyanddose-dependentlyincreasestheexpressionsofABCA1andABCG1atthemRNAandproteinlevelsinhumanTHP-1macrophages,andsucheffectisinvolvedinPPARγ.Leonurinehydrochloride(LH)showsprotectiveeffectoncellviabilityofHepG2andHL-7702cellsincubatedwithpalmiticacid(PA)offreefattyacid(FFA)for24h.Leonurinehydrochloride(125,250,500μM)improvescellularlipidaccumulationinHepG2andHL-7702cellsviaactivatingAMPK/SREBP1pathway.Leonurine(5,10,20µM)inhibitstheexpressionofiNOS,COX-2,PGE2,NO,TNF-α,andIL-6inIL-1β-inducedhumanchondrocytes,suppressesECMdegradationinhumanOAchondrocytes,andblocksIL-1β-inducedPI3KandAktphosphorylationinadose-dependentmanner.体内研究Leonurine(10mg/kg/d,p.o.)significantlyincreasestheexpressionsofPPARγ,LXRα,ABCA1andABCG1,anddecreasesbothTGandTClevelsinserumofmice.Leonurinehydrochloride(50,100,200mg/kg)improvesintracellularlipidaccumulationviaactivatingAMPK/SREBP1pathway,enhancesbiochemicalparameters,reduceshepaticlipoperoxideandincreasesantioxidantlevelsinmice.Leonurine(20mg/kg,p.o.)amelioratesosteoarthritisdevelopmentinmouseDMMmodel.化学性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于益母草。用途益母草碱具有活血、祛淤、调经、消水的作用。用途用于含量测定/鉴定/药理实验等药理药效:1．对子宫的作用益母草碱对兔、猫、犬、豚鼠等多种动物的子宫均呈兴奋作用2．对循环系统的作用小剂量益母草碱对离体蛙心有增强收缩作用，使用大量时反呈抑制现象。这种抑制现象可能由于迷走神经末梢兴奋所致。 |
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