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ARV-771 |
| CAS No.: |
1949837-12-0 |
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| 备注： |
中文名称ARV-771中文同义词化合物ARV-771;(2S,4R)-1-((2S)-2-(叔丁基)-15-((6S)-4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)-4,14-二氧代-6,10-二氧杂-3,13-二氮杂十五烷-1-OYL)-4-羟基-N-((S)-1-(4-(4-甲基噻唑-5-基)苯基)乙基)吡咯烷-2-甲酰胺;ARV-771游离态英文名称ARV-771英文同义词ARV-771;ARV771;ARV771;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-;(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-Chemicalbook3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide;EpigeneticReaderDomain,ARV-771,ARV771,inhibit,ARV771,PROTACs,InhibitorCAS号1949837-12-0分子式C49H60ClN9O7S2分子量986.65EINECS号相关类别抑制剂Mol文件1949837-12-0.mol结构式ARV-771性质密度1.39±0.1g/cm3(Predicted)储存条件Sealedindry,Storeinfreezer,under-20°C溶解度DMSO:65.92(最大浓度mg/mL);68.22(最大浓度mM)DMF:20.0(最大浓度mg/mL);20.7(最大浓度mM)DMF:PBS(pH7.2)(1:6):0.14(最大浓度mg/mL);0.14(最大浓度mM)乙醇:55.0(最大浓度mg/mL);56.92(最大浓度mM)形态结晶固体酸度系数(pKa)13.61±0.46(Predicted)颜色白色至浅黄色InChIKeyPQOGZKGXGLHDGS-BZTQNJCZNA-NARV-771用途与合成方法生物活性ARV-771是一种有效的pan-(bromodomainandextra-terminal)BET降解剂，一种新型的BET-PROTAC(proteolysis-targetingchimera)，对于BRD2(1)、BRD2(2)、BRD3(1)、BRD3(2)、BRD4(1)和BRD4(2)的Kd值分别为34nM、4.7nM、8.3nM、7.6nM、9.6nM和7.6nM。靶点TargetValueBRD2-BD2(Cell-freeassay)4.7nM(Kd)BRD3-BD2(Cell-freeassay)7.6nM(Kd)BRD4-BD2(Cell-freeassay)7.6nM(Kd)BRD3-BD1(Cell-freeassay)8.3nM(Kd)BRD4-BD1(Cell-freeassay)9.6nM(Kd)用途一种PROTAC类的有效BET降解剂。 |
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