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血卟啉二盐酸盐 |
| CAS No.: |
17696-69-4 |
| 分子式： |
C34H40Cl2N4O6 |
| 分子量： |
671.61 |
| 备注： |
中文名称血卟啉二盐酸盐中文同义词血卟啉IX二氯化氢;卤代卟啉盐酸盐;血卟啉二盐酸盐;二盐酸血紫素;血卟啉盐酸盐;血卟啉盐酸盐(一水);血紫素盐酸盐;盐酸血紫素英文名称HEMATOPORPHYRINDIHYDROCHLORIDE英文同义词21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;ematoporfirina;HEMATOPORPHYRINIXDIHYDROCHLORIDE;HEMATOPORPHYRINDIHYDROCHLORIDE;HAEMATOPORPHYRINDIHYDROCHLORIDECAS号17696-69-4分子式C34H39ClN4O6分子量635.16EINECS号241-699-4相关类别医药原料;NaturalPorphyrinsandDerivitives;Porphyrins;Biochemistry;MiscellaneousBiochemicals;porphine(porphyrin)ligandMol文件17696-69-4.mol结构式血卟啉二盐酸盐性质储存条件Inertatmosphere,RoomTemperature溶解度可溶于DMSO（少许）、甲醇（少许）形态固体颜色深红色水溶解性Insolubleinwater.Solubleinpyridine(5%).Merck14,4636BRN78957稳定性吸湿性EPA化学物质信息21H,23H-Porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-,dihydrochloride(17696-69-4)血卟啉二盐酸盐用途与合成方法应用有研究表明血卟啉二盐酸盐可用于制备具有高结晶速率的树脂组合物，其包含聚呋喃二甲酸亚烷基酯(polyalkylenefurandicarboxylate)树脂和卟啉化合物。该聚呋喃二甲酸亚烷基酯树脂优选为聚呋喃二甲酸亚丁基酯树脂。该卟啉化合物优选为血卟啉二盐酸盐(hematoporphyrindihydrochloride)。生物活性Hematoporphyrindihydrochloride(HematoporphyrinIXdihydrochloride)是一种光敏剂，是血红素结合蛋白亲和色谱底物。当暴露于红光下时，Hematoporphyrindihydrochloride可以诱导U87胶质瘤细胞凋Chemicalbook亡，并降低体内肿瘤的生长。体外研究Hematoporphyrin(20-120nM;60min)dose-dependentlyinhibitscellviabilityinU87andU251gliomacells,withIC50sof85and166nM,respectively.Hematoporphyrin(85nM;60min)inducescellapoptosisviainductionofROSinU87cells.Hematoporphyrin(85nM;60min)inducesmorphologicalchangesofU87cellsundertheredlight,includingshrinking,fragmentation.CellViabilityAssayCellLine:U87andU251cellsConcentration:20,40,60,80,100,120nMIncubationTime:60minResult:Inhibitedcellviabilityinadose-dependentmanner.Wasmoreeffectiveundertheredlightthanwhitelight.ApoptosisAnalysisCellLine:U87cellsConcentration:85nMIncubationTime:60minResult:InducedapoptoticnucleiinU87cellswithlowcelldensity.InducedtheROSanddecreasedthemitochondrialmembranepotential.体内研究Hematoporphyrin(5-10mg/kg;i.p.for2months)withtheirradiationofredlightrapidlydecreasesthetumorsizeofrats,duetonecrosiscausedbothbydirectactionofthephotoactivatedporphyrinonthetumorcellsandbysecondaryeffectsonbloodvessels.AnimalModel:Wistaralbinoratsofbothsexes(20d;60-80g)bearingasubcutaneoussolidYoshidahepatomaAH-130Dosage:5,10mg/kgAdministration:I.p.dailyduringtheinitial10daysandbiweeklyforthenext2monthsResult:Notumorcouldbepalpatedafewdaysafterexposureoftheratstolight.Theskinhealedcompletelyandregrowthofthehairoccurred.Massivecoagulationnecrosisofthetumor24hafterphototreatment(×40). |
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