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L-甲状腺素 |
| CAS No.: |
51-48-9 |
| 分子式： |
C15H11I4NO4 |
| 分子量： |
776.87 |
| 备注： |
中文名称L-甲状腺素中文同义词L-THYROXINEL-甲状腺素;L-甲状腺素/O-(4-羟基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸/3,5,3′,5′-四碘-L-甲状腺原氨酸/3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸/2-甲状腺素/L-Β-(3,5-二磺-4-羟基苯氧基)-3,5-二磺苯丙氨酸/左甲状腺素/T4;2-甲状腺素、左甲状腺素;L-甲壮腺素;L-甲状腺素(标准品);左甲状;3,5,3’,5’-四碘甲状腺胺酸;L-甲状腺激素英文名称L-Thyroxine英文同义词3,5,3’,5’-tetraiodothyronine;beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine;l-3,5,3’,5’-tetraiodothyronine;l-t4;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin;β-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine;3,5,3’,5’-TETRAIODO-L-THYRONINE;3,3’,5,5’-TETRAIODO-L-THYRONINCAS号51-48-9分子式C15H11I4NO4分子量776.87EINECS号200-101-1相关类别原料药;医药级;氨基酸;细胞生物学;兽药级;医药原料;饲料添加剂;小分子抑制剂;原料;小分子抑制剂，天然产物;医药中间体;杂环化合物;激素;AminoAcids;Organics;HeterocyclicCompounds;AminoAcids&Derivatives;Intermediates&FineChemicals;Pharmaceuticals;IsotopeLabeledCompounds;生化试剂;生物化学品;Inhibitors;Pyridines,氟化学;氨基酸类;内分泌与激素;化合物;化学试剂;对照品;其他生化试剂;前列素系列;有机中间体;其他;中药对照品;化工原料;主营产品;化学试剂;通用生化试剂-氨基酸;医用原料;Aromatics;IsotopeLabelledCompounds;SYNTHROID;Isolabel;OtherAPIsMol文件51-48-9.mol结构式L-甲状腺素性质熔点235°C比旋光度-5º(1NNaOH:EtOH1:2)密度2.4440(estimate)闪点9℃储存条件Keepindarkplace,Inertatmosphere,2-8°C溶解度以50mg/ml溶于4M氢氧化铵的甲醇溶液酸度系数(pKa)2.2(at25℃)形态粉末沸点576.3±50.0°C(Predicted)颜色白色至浅棕色水溶解性insoluble敏感性LightSensitiveMerck9491BRN2228515InChIKeyXUIIKFGFIJCVMT-LBPRGKRZSA-NCAS数据库51-48-9(CASDataBaseReference)EPA化学物质信息L-Thyroxine(51-48-9)L-甲状腺素用途与合成方法生物活性L-Thyroxine(NSC36397)是甲状腺素的合成形式，是一种激素替代药物。靶点HumanEndogenousMetabolite体内研究Deiodinases(DIOs),whichcatalysetheconversionofthyroxine(pro-hormone)totheaChemicalbookctivethyroidhormone,areassociatedwiththyroidstimulatinghormone(TSH)levels.DIO1andDIO2catalyzeactivationofthyroidhormonesecretionincontrasttoDIO3playingroleinactivationofthesecretion.ActivitiesofDIO1andDIO2playpivotalroleinthenegativefeedbackregulationofpituitaryTSHsecretion.L-Thyroxine(T4)andTriiodothyronine(T3)hormonesareknowntomodulatetheexpressionofionicchannels,pumpsandregulatorycontractileproteins.Moreover,thyroidhormoneshavebeenshowntoinfluencecalciumhomeostasisandfluxresponsibleforexcitationandcontractility,withL-ThyroxineandTriiodothyroninemodulatingitspharmacologicalcontrolandsecretion.Inratsfed12weekswiththeiodine-freediet,asignificantdecreaseinthelevelsofbothTriiodothyronineandL-Thyroxineisobservedwhencomparedtothecontrolgroupfedwithstandarddiet(p<0.001).InthegrouptreatedwithlowdosesofL-Thyroxine,anincreaseinL-Thyroxinelevelsisobserved(p=0.02)whileTriiodothyroninelevelsremainvirtuallysimilartothecontrolgroup(p=0.19).RatstreatedwithhighdosesofL-ThyroxinedisplayasignificantincreaseinbothTriiodothyronineandL-Thyroxinecirculatingconcentrationscomparedtothenon-treatedhypothyroidgroup(p<0.001andp=0.004,respectively)andasignificantincreaseinL-Thyroxinelevelswhencomparedtothecontrolvalues(p=0.03).化学性质白色结晶。Mp235-236℃(分解)，比旋光度[α]20D-4.4°(3%，0.13mol/L氢氧化钠，70%乙醇)，在0.4mol/LNaOH溶液中325nm波长处有最大吸收、0.4mol/LHCl溶液中295nm波长处有最大吸收。本品溶于碱溶液，不溶于水、乙醇和乙醚。用途生化研究；拟甲状腺素药物。用途L-甲状腺素(T4)和三吲哚-L-甲状腺原氨酸(triiodo-L-thyronine，T3)是含吲哚激素，是由甲状腺滤泡细胞里的甲状腺球蛋白产生的。L-甲状腺素通过影响DNA转录和蛋白质合成来刺激代谢和调控生长和发育。生产方法以3，5-二碘-L-酪氨酸为主要原料。 |
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