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牛磺鹅去氧胆酸 |
| CAS No.: |
516-35-8 |
| 分子式： |
C26H45NO6S |
| 分子量： |
499.7 |
| 备注： |
中文名称牛磺鹅去氧胆酸中文同义词牛磺鹅去氧胆酸标准品;牛磺鹅去氧胆酸;TAUROCHENODEOXYCHOLICACID牛磺鹅去氧胆酸英文名称:2-[4-(3,7-DIHYDROXY-10,13-CAS号:516-35-8分子式:C26H45NO6S分子量:499.7含量98%白色粉末牛磺鹅去氧胆酸钠用于生化研究;纯天然牛磺鹅去氧胆酸含量98%白色粉末中文同义词:牛磺鹅去氧胆酸;【纯天然牛磺鹅去氧胆酸】医药含量95%白色粉末;纯天然牛磺鹅去氧胆酸;【纯天然牛磺鹅去氧胆酸】医药含量98%白色粉末;牛磺鹅去氧胆酸?,99.5%英文名称Taurochenodeoxycholicacid英文同义词2-(4-(3,7-dihydroxy-10,13-diMethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanaMido)ethanesulfonicacid;Taurocholicchenodeoxycholicacid;2-((R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonicacid;Taurochenodeoxycholicacid,99.5%;2-{[(3alpha,5beta,7alpha,20xi)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonicacid;2-[4-(3,7-dihydroxy-10,13-;Taurochenodeoxycholicacid;C05465CAS号516-35-8分子式C26H45NO6S分子量499.7EINECS号相关类别原料药;医药原料;中药对照品;对照品、标准品;其他原料;对照品;植物提取物;标准品;分析试剂标准品;对照品-中药对照品;标准品-中药标准品;标准品，对照品;分析试剂标准品;Intermediates&FineChemicals;Metabolites&Impurities;Pharmaceuticals;SteroidsMol文件516-35-8.mol结构式牛磺鹅去氧胆酸性质熔点186-200°C密度1.216±0.06g/cm3(Predicted)储存条件Sealedindry,RoomTemperature溶解度可溶于氯仿、甲醇形态固体酸度系数(pKa)1.42±0.50(Predicted)颜色白色至浅棕色牛磺鹅去氧胆酸用途与合成方法生物活性Taurochenodeoxycholicacid(12-Deoxycholyltaurine)是动物胆汁酸的主要生物活性物质之一。TaurochenChemicalbookodeoxycholicacid可诱导细胞凋亡(apoptosis)，并具有明显的抗炎和免疫调节作用。靶点HumanEndogenousMetabolite体外研究Taurochenodeoxycholicacid(12-Deoxycholyltaurine)dramaticallyimprovestheapoptosisrateofNR8383cellsinaconcentration-dependentmanner.Inthemeantime,TaurochenodeoxycholicacidsignificantlyaugmentsPKCmRNAlevels,activitiesandincreasesJNK,caspase-3andcaspase-8mRNAexpressionlevels,activities.体内研究Taurochenodeoxycholicacid(12-Deoxycholyltaurine;0.05,0.1g/kg)decreasesthepulmonarycoefficientinthemodelmiceandreducesthepathologicaldamagesontheirlungs;itcandecreasetheexpressionlevelsofTNF-αandTIMP-2inpulmonarytissuesinthepulmonaryfibrosismiceandhasnosignificanteffectsonMMP2.Taurochenodeoxycholicacidsignificantlynormalizestheclinicalinflammatoryparameters,preventedindomethacin-inducedincreasesinthebiliarycontentsofsecondarybileacidsandhydrophobicityindex,andtendedtoattenuatetheintestinalinflammation.Taurochenodeoxycholicacidsignificantlysuppressespawswellingandpolyarthritisindex,increasesthelossbodyweightandindexofthymusandspleen,andamendsradiologicchangesinAArats.TheoverproductionandmRNAexpressionofTNF-α,IL-1βandIL-6areremarkablysuppressedinserumandsynoviumtissueofallTCDCA-treatedrats.化学性质白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于动物胆汁。用途用于含量测定/鉴定/药理实验等。 |
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