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别孕烯醇酮 |
| CAS No.: |
516-55-2 |
| 分子式： |
C21H34O2 |
| 分子量： |
318.50 |
| 备注： |
中文名称别孕烯醇酮中文同义词异孕烷醇酮;1-[(8R,9S,10S,13S,14S,17S)-3-羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊烷并[A]菲-17-基]乙酮;别孕烷醇酮;别孕烯醇酮别孕酮中间体;5ALPHA-孕甾-3BETA-醇-20-酮,四氢孕酮(17A,21,21,21-D4,97%+)96%PURE;5ALPHA-孕甾-3BETA-醇--20-酮,四氢孕酮非标;5ALPHA-孕甾-3BETA-醇-20-酮;2H4]-异孕酮英文名称ALLOPREGNANOLONE英文同义词3-beta-allopregnanolone;3-beta-hydroxy-5-alpha-pregnan-20-on;3-hydroxy-,(3-beta,5-alpha)-pregnan-20-on;3-Hydroxypregnan-20-one;5alpha-Pregnan-20-one,3beta-hydroxy-;5alpha-Pregnane-3beta-ol-20-one;Allopregnan-3beta-ol-20-one;Allopregnane-3beta-ol-20-oneCAS号516-55-2分子式C21H34O2分子量318.49EINECS号208-224-2相关类别中药对照品;别孕酮中间体;SteroidsMol文件516-55-2.mol结构式别孕烯醇酮性质熔点200℃比旋光度D27+91.2°(c=0.4inethanol)沸点431.2±18.0°C(Predicted)密度1.1g/cm3储存条件Refrigerator溶解度可溶于氯仿（少许）、甲醇（少许）酸度系数(pKa)15.12±0.Chemicalbook70(Predicted)形态固体颜色白色至类白色CAS数据库516-55-2(CASDataBaseReference)别孕烯醇酮用途与合成方法用途异丙孕酮用于制备抗菌和抗白血病类固醇。中间体。生物活性Alloepipregnanolone是一种具有催眠和镇静作用的孕酮，它能干扰乙醇抗焦虑作用的快速耐受。靶点HumanEndogenousMetabolite体内研究Onday2,pretreatmentwitha0.20mg/kgdoseofAlloepipregnanoloneblocksthedevelopmentofrapidtolerancetotheanxiolyticeffectofethanol.However,thereisasignificantdecreaseintheanxiolyticeffectinthecontrolgroupsthatreceivedethanolonbothdays(EE),suggestingthatthe1.5g/kgdoseofethanolresultsinrapidtolerance.Theposthocanalysisconfirmsthatthe0.20mg/kgpretreatmentwithAlloepipregnanoloneblockstherapidtolerancecomparedtothecontrolgroups,althoughthe0.10mg/kgdoseonlypartiallyblocksthedevelopmentofsuchtolerance.However,the0.05mg/kgdosehasnoeffectonthedevelopmentofrapidtolerancetoethanol. |
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