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吡咯烷二硫代甲酸铵盐 |
| CAS No.: |
5108-96-3 |
| 分子式： |
C5H12N2S2 |
| 分子量： |
164.29 |
| 备注： |
中文名称吡咯烷二硫代甲酸铵盐中文同义词吡咯烷二硫代甲酸铵;四次甲基二硫代氨基甲酸铵;四亚甲基二硫代氨基甲酸铵;1-吡咯烷硫代羧酸铵盐/吡咯二硫代甲酸铵;1-吡咯烷羰基二硫酸铵盐;N-吡咯烷二硫代甲酸铵;1-吡咯烷硫代羧酸铵盐、吡咯二硫代甲酸铵、1-吡咯烷二硫代羧酸铵盐;吡咯烷二硫代甲酸铵盐英文名称Ammonium1-pyrrolidinedithiocarbamate英文同义词1-Pyrrolidinecarbodithioicacid,ammoniumsalt,95%;AmmoniumPyrrolidine-N-dithiocarba;PDTCPyrrolidinedithiocarbamate,ammoniumderivative;Ammoniumpyrrolidinedithiocarbamate,1-Pyrrolidinecarbodithioicacidammoniumsalt,APDC,Ammoniumpyrrolidinecarbodithioate,PDC,PDTC;Ammoniumpyrrolidine;1-Pyrrolidinecarbodithioicacid,aMMoniuMsalt,98%25GR;AmmoniumPyrrolidine-N-dithiocarbamate1-PyrrolidinecarbodithioicAcidAmmoniumSaltPyrrolidine-N-dithiocarbamicAcidAmmoniumSalt;PYRROLIDINE-1-DITHIOCARBOXYLICACIDAMMOCAS号5108-96-3分子式C5H9NS2.H3N分子量164.3EINECS号225-834-4相关类别有机化工原料;生化试剂;酶抑制剂;细胞信号和神经生物学;细胞生物学试剂;化学试剂;化工原料;生化试剂-其他化学试剂;合成材料中间体-高分子材料;有机原料;医药中间体;细胞生物学;标准品;NitricOxide;格氏试剂;中药对照品;有机化工原料;通用生化试剂-有机酸Mol文件5108-96-3.mol结构式吡咯烷二硫代甲酸铵盐性质熔点153-155°C(lit.)密度1.117(estimate)折射率1.5300(estimate)储存条件Storeat+2°Cto+8°C.溶解度190g/l形态粉末/固体颜色白色至类白色PH值6-7(50g/l,H2O,20℃)水溶解性50g/L(20ºC)敏感性HygroscopicBRN3730472稳定性稳定的。与强氧化剂不相容。CAS数据库5108-96-3(CASDataBaseReference)EPA化学物质信息1-Pyrrolidinecarbodithioicacid,ammoniumsalt(5108-96-3)吡咯烷二硫代甲酸铵盐用途与合成方法用途吡咯烷二硫代甲酸铵盐在包括金属螯合作用在内的生物化学应用中很有用。它被用来防止一氧化氮合酶的诱导。抑制白血病HL-60细胞的凋亡也是非常重要的。生物活性PyrroliChemicalbookdinedithiocarbamateammonium(Ammoniumpyrrolidinedithiocarbamate,APDC,PDTC,Pyrrolidinedithiocarbamicacidammoniumsalt)是NF-κB的有效抑制剂，抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。靶点TargetValueNF-κB()体外研究PretreatmentofcellswithPyrrolidinedithiocarbamateammonium(Ammoniumpyrrolidinedithiocarbamate;3-1000μM)dose-dependentlyattenuateIL-8production.Furthermore,pyrrolidinedithiocarbamateammonium(100μM)suppressestheaccumulationofIL-8mRNA.PyrrolidinedithiocarbamateammoniuminhibitstheactivationofNF-κB,becauseitsuppressesbothNF-κBDNAbindingandNF-κB-dependenttranscriptionalactivity.NF-κBinhibitionwithpyrrolidinedithiocarbamateammoniumdecreaseIL-8productionbyintestinalepithelialcells.体内研究TheDSS+pyrrolidinedithiocarbamateammonium-treatedgroupIIexhibitssuppressionofshorteningofintestinallengthandreductionofDAIscore.ActivatedNF-κBlevelandIL-1βandTNF-αlevelsaresignificantlylowerinDSS+pyrrolidinedithiocarbamateammonium-treatedgroupII.ThesefindingssuggestthatsuppressionofNF-κBactivitybypyrrolidinedithiocarbamateammoniumcandelaythehealingofmucosaltissuedefects(erosionsorulcers)arisingfrominflammation,butthatitcanstronglysuppresstheexpressionofinf-lammatorycytokines(IL-1βandTNF-α),resultinginsignificantalleviationofcolitis.pyrrolidinedithiocarbamateammoniumisusefulforthetreatmentofulcerativecolitis. |
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