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3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇 |
| CAS No.: |
1568-80-5 |
| 分子式： |
C21H24O2 |
| 分子量： |
308.45 |
| 备注： |
中文名称3,3,3’,3’-四甲基-1,1’-螺BI(茚满)-6,6’-二醇中文同义词螺二茚满;3,3,3’,3’-四甲基螺环二酚;3,3,3’,3’-四甲基-2,2’,3,3’-四氢-1,1’-螺二[茚满]-6,6’-二醇;螺双茚满;3,3,3’,3’-四甲基-1,1’-螺BI(茚满)-6,6’-二醇;3,3,3’,3’-四甲基-2,2’,3,3’-四氢-1,1’-螺联[茚]-6,6’-二醇;HIV-1整合酶抑制剂8;3,3,3,3-四甲基-2,2,3,3-四氢-1,1-螺双[茚]-6,6-二醇英文名称SPIROBIINDANE英文同义词SPIROBIINDANE;2,2’’,3,3’’-TETRAHYDRO-3,3,3’’,3’’-TETRAMETHYL-1,1’’-SPIROBI-1H-INDENE-6,6’’-DIOL;tetrahydrotetramethyl-1,1’-spirobi-1H-indene-6,6’-diol;3,3,3’,3’-Tetramethyl-1,1’-spirobi[indan]-6,6’-diol;3,3,3’,3’-Tetramethyl-2,2’,3,3’-tetrahydro[1,1’-spirobi[1H-indene]]-6,6’-diol;3,3,3’,3’-Tetramethyl-2,2’,3,3’-tetrahydro-1,1’-spirobi[1H-indene]-6,6’-diol;6,6’-Dihydroxy-3,3,3’,3’-tetramethyl-1,1’-spirobiindan;6,6’-Dihydroxy-3,3,3’,3’-tetramethyl-1,1’-spirobiindaneCAS号1568-80-5分子式C21H24O2分子量308.41EINECS号相关类别醇;化学试剂Mol文件1568-80-5.mol结构式3,3,3’,3’-四甲基-1,1’-螺BI(茚满)-6,6’-二醇性质熔点213-214°C沸点478.5±45.0°C(Predicted)密度1.21±0.1g/cm3(Predicted)储存条件Storeat-20°C溶解度DMSO：125mg/mL（405.30mM；需要超声波）Chemicalbook酸度系数(pKa)9.98±0.60(Predicted)形态固体颜色白色至米白色CAS数据库1568-80-5EPA化学物质信息1,1’-Spirobi[1H-indene]-6,6’-diol,2,2’,3,3’-tetrahydro-3,3,3’,3’-tetramethyl-(1568-80-5)3,3,3’,3’-四甲基-1,1’-螺BI(茚满)-6,6’-二醇用途与合成方法生物活性HIV-1integraseinhibitor8是HIV-1整合酶(HIV-1integrase)抑制剂，化合物8。体外研究HIV-1integraseinhibitor8isagainst3′-processing(TC)andstrand-transfer(ST)activitiesinthepresenceofMn2+asthecationiccofactorbygelassaywithIC50valuesof275µMand200µM,respectively.Itinhibitsthestrand-transfer(ST)activitywithanIC50valueof200µM.TheDNArelaxationactivityofMCVtopoisomeraseismonitoredbygelelectrophoresis,whileDNAcleavageandreligationactivitiesweremonitoredusingamicrotiterassay.HIV-1integraseinhibitor8inhibitsMCVtopoisomeraseandDNAreligationwithIC50valuesof500µMand200µM,respectively.Thisresultdemonstratesthatcompound8isinactiveagainsttopoisomeraseinbothassays.HIV-1integraseinhibitor8inducescellcytotoxicityandyieldsaLD50(doseatwhichthesignalisreduced50%duetocelldeath)of20μMinHeLacells. |
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