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芥子酸 |
| CAS No.: |
530-59-6 |
| 分子式： |
C11H12O5 |
| 分子量： |
224.21 |
| 备注： |
中文名称芥子酸中文同义词咖啡酸反式异构体;芥子酸;3,5-二甲氧基-4-羟基-反式-苯乙烯酸,;3,5-二甲氧基-4-羟基苯丙烯酸;順13-二十二烯酸;順二十二碳-13-烯酸;3,5-二甲氧基-4-羥基桂皮酸;3,5-二甲氧基-4-羟基肉桂酸[MALDI-TOF/MS基质]英文名称4-Hydroxy-3,5-dimethoxycinnamicacid英文同义词3,5-Dimethoxy-4-hydroxycinnamicacid,4-Hydroxy-3,5-dimethoxycinnamicacid,Sinapicacid;3,5-Dimethoxy-4-hydroxycinnamicacid,4-Hydroxy-3,5-dimethoxy-cinnamicacid,Sinapicacid,Sinapinicacid;3,5-Dimethoxy-4-hydroxycinnamicacid,98%,predominantlytransisomer;3-(3,5-Dimethoxy-4-hydroxyphenyl)acrylicacid;3-(4-Hydroxy-3,5-dimethoxyphenyl)propenoicacid;3,5-Dimethoxy-4-hydroxybenzeneacrylicacid;Synapoicacid;3-(4-Hydroxy-3,5-diMethoxyphenyl)-2-propenoicAcidCAS号530-59-6分子式C11H12O5分子量224.21EINECS号208-487-3相关类别植物提取物;植物生化提取物;医药中间体;营养学研究;生化试剂;对照品;标准品-对照品;其他生化试剂;生化试剂-其他化学试剂;羰基化合物;对照品;苯丙素;标准品，对照品;AromaticCinnamicAcids,EstersandDerivatives;AnalyticalChemistry;MassSpectrometry;MatrixMaterials(MALDI-TOF-MS);Alliumcepa(Onion);Alliumsativum(Garlic);Armoraciarusticana(Horseradish);Berberissp.;BuildingBlocks;C11toC12;CarbonylCompounds;CarboxylicAcids;ChemicalSynthesis;Cichoriumintybus(Chicory);Linumusitatissimum(Flax);NutritionResearch;OrganicBuildingBlocks;PhytochemicalsbyPlant(Food/Spice/Herb);VacciniummacroChemicalbookcarpon(Cranberry);UltraPureMALDIMatrices;proteinmod;中药对照品Mol文件530-59-6.mol结构式芥子酸性质熔点~202°C沸点285.61°C(roughestimate)密度1.1478(roughestimate)折射率1.4720(estimate)储存条件Keepindarkplace,Sealedindry,RoomTemperature溶解度H2O：微溶酸度系数(pKa)4.53±0.10(Predicted)形态粉末颜色白色气味(Odor)无味水溶解性insolubleBRN2130006稳定性稳定的。与强氧化剂、强碱不相容。易燃。LogP0.997(est)CAS数据库530-59-6(CASDataBaseReference)NIST化学物质信息Cinnamicacid,4-hydroxy-3,5-dimethoxy-(530-59-6)芥子酸用途与合成方法生物活性Sinapinicacid(Sinapicacid)是一种天然的小羟基肉桂酸，属于苯基丙烷类，通常在MALDI质谱中用作基质。Sinapinicacid(Sinapicacid)作为HDAC的抑制剂，IC50为2.27mM，并且还抑制ACE-1活性。靶点TargetValueHDAC()ACE1()体外研究SinapinicacidactsasaninhibitorofHDAC,withanIC50of2.27mM.SinapinicacidalsoinhibitsACE-Iactivity.SinapinicacidinhibitsHDACactivityinHeLacells,suppressesthegrowthofHeLaandHT29cellswithIC50sof0.91±0.02mMand1.6±0.02mMat72h,respectively,inducesapoptosisofthesecancercells.体内研究Sinapinicacid(5or25mg/kg,p.o.dailyfor4weeks)increasestheserumestradiolconcentration;decreasesinsulinresistanceandthetriglycerideandtotalcholesterolconcentrations;andfavorablyaffectstheparametersofantioxidantabilities(reducesglutathione,superoxidedismutase)andoxidativedamageinrats.化学性质白色粉末，溶于三氯甲烷，乙醚，甲醇，来源于菜粕。用途用于含量测定/鉴定/药理实验等 |
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