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乙酰辅酶 A 钠盐 |
| CAS No.: |
102029-73-2 |
| 分子式： |
C23H38N7O17P3S |
| 分子量： |
809.57 |
| 备注： |
中文名称乙酰辅酶A钠盐中文同义词乙酰辅酶A钠盐≥93%(HPLC)(-20℃);乙酰辅酶A钠盐;乙酰辅酶A;乙醯COA;乙醯輔酶A;乙酰辅酶A钠;乙酰辅酶A三钠盐;ACETYLCOENZYMEA乙酰辅酶A英文名称AcetylcoenzymeAsodiumsalt英文同义词C2:0;ACETHYLCOENZYMEASODIUMSALT;ACETYLCOENZYMEASODIUMSALT;ACETYLCOENZYMEA(C2:0)SODIUMPREPAREDENZYMATICA;ACETYLCOENZYMEA;Acethylcoenzymealphasodiumsalt;acetylcoa;Acetyl-CoenzymACAS号102029-73-2分子式C23H38N7O17P3S.3Na分子量809.57EINECS号相关类别化学试剂;对照品;氨基酸;生化试剂-酶、辅酶;有机砌块;分子生物学;氨基酸类;生化试剂-酶类;生化试剂-酶和辅酶;生化试剂;通用生化试剂-酶与辅酶;生命科学;试剂盒-生化试剂盒;生物试剂Mol文件102029-73-2.mol结构式乙酰辅酶A钠盐性质储存条件-20°C溶解度H2O:100mg/mL形态粉末颜色白色至米白色InChIKeyZSLZBFCDCINBPY-KMYLAXNMSA-N乙酰辅酶A钠盐用途与合成方法应用及发展前景乙酸乙酯是清香型白酒的主体香，一直备受关注。通过基因工程手段提高酿酒酵母分泌乙酰辅酶A的能力，从而提高乙酸乙酯生成量。通过ACH1基因缺失的α5ΔACH1菌株表达发现，乙酰辅酶A含量较亲本菌株α5稍有提高，但对提高乙酸乙酯生成量的效果并不明显，分析原因可能是ACH1基因定位于线粒体中，其增加的是线粒体中乙酰辅酶A的含量，线粒体中的乙酰辅酶A无法流向乙酸乙酯的合成。在ACH1基因缺失的基础上，过表达ACS1和ACS2基因得到工程菌株α5-A1和α5-A2，乙酸乙酯生成量分别比亲本菌株α5提高26.12%和23.70%；乙酰辅酶A含量分别比α5ΔACH1提高了80.33%和52.79%；结果表明，过表达ACS1和ACS2基因均能提高乙酰辅酶A含量和乙酸乙酯生成量，且乙酸乙酯生成量和胞内乙酰辅酶A的增加量呈正相关。在过表达ACS1和ACS2基因的基础上，过表达醇乙酰基转移酶ATF1基因得到工程菌株A1-ATF1和A2-ATF1，乙酸乙酯含量分别为72.52mg/L和44.80mg/L，分别是单独过表达ATF1基因a5-ATF1的204.14%和125.67%，且ΔA-ATF1比α5-ATF1产乙酸乙酯显著增加，结果表明，在底物乙酰辅酶A充足的条件下，提高醇乙酰基转移酶活性，能够提高乙酸乙酯的生成量。生物活性AcetylCoenzymeAtrisodium(Acetyl-CoAtrisodium)是一种重要的代谢中间产物。AcetylCoenzymeAtrisodium是糖酵解丙酮Chemicalbook酸进入三羧酸(TCA)循环的实际分子，是脂质合成的关键前体，并且是乙酰基乙酰化的唯一供体，还是一种丙酮酸羧化酶(PC)的有效变构活化剂。体外研究Acetyl-coenzymeA(Acetyl-CoA)isamembrane-impermeantmoleculeconstitutedbyanacetylmoiety(CH3CO)linkedtocoenzymeA(CoA),aderivativeofvitaminB5andcysteine,throughathioesterbond.Asthioesterbondsareenergyrich,thechemicalstructureofacetyl-CoAfacilitatesthetransferoftheacetylmoietytoavarietyofacceptormolecules,includingaminogroupsonproteins.Inmostmammaliancells,Acetyl-coenzymeA(Acetyl-CoA)ispredominantlygeneratedinthemitochondrialmatrixbyvariousmetaboliccircuitries,namelyglycolysis,β-oxidation,andthecatabolismofbranchedaminoacids.CytosolicAcetyl-coenzymeAistheprecursorofmultipleanabolicreactionsthatunderliethesynthesisoffattyacidsandsteroids,aswellasspecificaminoacidsincludingglutamate,proline,andarginine.体内研究Micedeprivedoffood(butwithaccesstowateradlibitum)for24hrexhibitasignificantreductionintotalAcetyl-coenzymeA(Acetyl-CoA)levelsinseveralorgans,includingtheheartandmuscles,correspondingtoadecreaseinproteinacetylationlevels.However,thesameexperimentalconditionshavenomajoreffectsonAcetyl-coenzymeAconcentrationsinthebrainandactuallyincreasehepaticAcetyl-coenzymeAandproteinacetylationlevels.EthanolintakeaugmentsAcetyl-coenzymeAlevelsinhepaticmitochondria. |
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