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S-腺苷高半胱氨酸水解酶 |
CAS No.: |
9025-54-1 |
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中文名称S-腺苷高半胱氨酸水解酶中文同义词S-(5’-腺苷基)-L-高半胱氨酸水解酶;S-(5′-腺苷)-L-同型半胱氨酸水解酶来源于兔红细胞;S-腺苷高半胱氨酸水解酶;腺苷高半胱氨酸水解酶;S(5′-腺苷)-L-同型半胱氨酸水解酶;S-腺苷-L-同型半胱氨酸水解酶SAHH;腺苷高半胱氨酸水解酶(SAHH);ANTI-SAHHANTIBODY-S腺苷L-同型半胱氨酸水解酶抗体英文名称EC3.3.1.1英文同义词S-ADENOSYL-L-HOMOCYSTEINEHYDROLASE;EC3.3.1.1;S-adenosyl-L-homocysteinehydrolase*fromrabbitE;S-ADENOSYL-L-HOMOCYSTEINEHYDROLASEFROMRABBITERY;s-(5’-adenosyl)-l-homocysteinehydrolasefromrabbiterythrocytes;5-adenyl-L-homocysteinehydrolase;ANTI-SADENOSYLHOMOCYSTEINEHYDROLASE(ACHY)(C-TERMINAL)antibodyproducedinrabbit;AHCYCAS号9025-54-1分子式分子量0EINECS号相关类别酶制剂;氨基酸;生化试剂-酶类;酶类;化学试剂;生化试剂-酶和辅酶;GeneRegulationMetabolomics;3.3.x.xActingonethers;3.x.x.ChemicalbookxHydrolases;CellSignalingandNeuroscience;GeneRegulationandExpression;GeneralMetabolicEnzymes;GeneralMetabolicEnzymesA-HEnzymeClassIndexMol文件MolFile结构式S-腺苷高半胱氨酸水解酶性质储存条件−70°C形态缓冲甘油水溶液CAS数据库9025-54-1S-腺苷高半胱氨酸水解酶用途与合成方法概述来源于S-腺苷蛋氨酸(S-adenosylmethioine,AdoMet)的甲基在特异的转甲基酶作用下可转移到各种受体分子(如:蛋白、核酸和小分子)上,S-腺苷高半胱氨酸(S-adenosylhomocysteine,AdoHcy)是所有AdoMet依赖的转甲基反应的产物,而S-腺苷高半胱氨酸水解酶(EC3.3.1.1)对AdoMet依赖的转甲基反应起着重要的调节作用。目前所知,在真核生物中S-腺苷高半胱氨酸水解酶催化S-腺苷高半胱氨酸水解生成腺苷(adenosine,Ado)和高半胱氨酸(homocysteine,Hcy)是S-腺苷高半胱氨酸代谢的唯一途径。S-腺苷高半胱氨酸作为AdoMet依赖的转甲基反应的竞争性抑制剂,当S-腺苷高半胱氨酸水解酶受到抑制时,将导致细胞内S-腺苷高半胱氨酸的积累,引起S-腺苷高半胱氨酸与AdoMet浓度比升高,进而抑制AdoMet依赖的转甲基反应,最终由于细胞内S-腺苷高半胱氨酸水平失控而产生细胞毒性。 |
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