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栀子苷 |
| CAS No.: |
24512-63-8 |
| 分子式： |
C17H24O10 |
| 分子量： |
388.37 |
| 备注： |
中文名称栀子苷中文同义词栀子苷(京尼平苷,去羟基栀子甙,枝子苷);桷子素葡萄糖苷;枝子苷;京尼平苷,去羟基栀子甙,枝子苷;京尼平苷/栀子苷标准品;栀子苷(分析标准品);京尼平苷/栀子苷;京尼平甙(标准品);栀子苷英文名称Geniposide英文同义词GENIPOSIDE;Methyl(1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate;glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-,methylester,(1S,4aS,7aS)-;(1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-hydroxymethylcyclopenta[c]pyran-4-carboxylicacidmethylester;1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylicacidmethylester;Geniposide,98%;OleaeuropaeaL;GeniposidicCAS号24512-63-8分子式C17H24O10分子量388.37EINECS号植物来源栀子相关类别中草药成分;植物提取物;中药对照品;标准品;对照品,标准品;分析标准品;对照品;其他原料;标准品-对照品;植物成分单体;合成试剂;中药标准品;Iridoids;Standardextract;NaturalPlantExtract;Glucagonreceptorandrelated;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;原料药;糖;原料;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物;标准品-中药标准品;标准品-中药标准品;环烯醚萜;动植物提取;天然高含量单体;主营推荐产品;通用生化试剂-天然产物;日用化学品Mol文件24512-63-8.mol结构式栀子苷性质熔点160.0to164.0°C沸点641.4±55.0°C(Predicted)密度1.54±0.1g/cm3(Predicted)储存条件2-8°C溶解度H2O：≥5mg/mL酸度系数(pKa)12.80±0.70(Predicted)形态粉末颜色白色至米色稳定性吸湿性LogP-1.920(est)CAS数据库24512-63-8(CASDataBaseReference)栀子苷用途与合成方法简介京尼平苷又称栀子甙、京尼平甙，外观为棕色至白色结晶性粉末，气微，无苦味，是从茜草科植物栀子的干燥成熟果实中提取的一种环烯醚萜苷类化合物，具有显著的促进胆汁的分泌作用。并能降低血中胆红素，可促进血液中胆红素迅速排泄。药理作用栀子苷对溶血性链球菌和皮肤真菌有抑制作用。有解热、镇痛、镇静、降压及止血作用。泻火除烦，清热利湿，凉血解毒，消肿止痛。主治热病心烦Chemicalbook，躁扰不宁，高热烦躁，神昏谵语，黄疸尿赤，热淋涩痛，血热吐衄，目赤肿痛，火毒疮疡；外治扭挫伤痛。生物活性Geniposide是GardeniajasminoidesEllis果实分离得到的一种环烯醚萜苷类。体外研究Geniposideexhibitsavarietyofactivities,suchasonantithrombosis,anti-inflammation,anti-diabetes,anti-atherosclerosis,antidepression,healingAlzheimer’sdisease(AD),anti-hypertension,toxicology,anduntowardreactionaresummarized.GeniposidemarkedlydeclinestheproductionofIL-8,IL-1βandMCP-1inOGD-inducedbrainmicrovascularendothelialcells,theexpressionofP2Y14receptorissignificantlydown-regulated,thephosphorylationofRAF-1,MEK1/2,ERK1/2aresuppressed.体内研究Geniposide(200and400mg/kg)significantlydecreasesthebloodglucose,insulinandTGlevelsindiabeticmiceinadose-dependentmanner.ThiscompoundalsodecreasestheexpressionofGPandG6PaseatmRNAandimmunoreactiveproteinlevels,aswellasenzymeactivity.Geniposide(20.0,40.0,or80mg/kg)significantlyreversestheexcessive,alcohol-inducedelevationinbothserumALT/ASTandhepaticLPOlevels.Geniposideupregulatestheexpressionofhemeoxygenase-1(HO-1)toattenuatethecellapoptosisinducedby3-morpholinosydnoniminehydrochloride(SIN-1)inprimaryculturedhippocampalneurons.Geniposideinhibitsphotochemistry-inducedthromboembolismmodelinvivo.GeniposideareveryeffectivedepressantsonNF-κBbyinterruptingIκBdegradation.化学性质易溶于水，溶于乙醇，不溶于石油醚。来源于茜草科植物栀子(GardeniajasminoidesEllis)果实用途用于含量测定/鉴定/药理实验等。药理药效:栀子苷具有缓泻、镇痛、利胆、抗炎、治疗软组织损伤以及抑制胃液分泌和降低胰淀粉酶等作用。用途一种环烯醚萜苷具有多种生物活性，包括神经保护、抗糖尿病、抗增殖和抗氧化活性。栀子苷已被证明是调节Nrf2的易位，并通过PI3K/Akt信号通路上调下游抗氧化蛋白HO-1的表达。胰高血糖素样肽-1（GLP-1）受体也可能在栀子苷诱导的HO-1表达中发挥关键作用。 |
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