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8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE |
| CAS No.: |
608512-97-6 |
| 分子式： |
C13H8N4OS |
| 分子量： |
268.29 |
| 备注： |
中文名称8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE中文同义词化合物PKR-IN-C16;8-((1H-咪唑-4-基)亚甲基)-6,8-二氢-7H-噻唑并[5,4-E]吲哚-7-酮;咪唑氧吲哚PKR抑制剂;咪唑氧吲哚PKR抑制剂C16;6,8-二氢-8-(1H-咪唑-5-基甲基)-7H-吡咯醇[2,3-G]苯并噻唑-7-一英文名称8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE英文同义词8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE;PKRINHIBITOR;6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one;Imidazolo-oxindolePKRinhibitorC16;GW506033X;(Z)-8-((1H-Imidazol-4-yl)methylene)-6H-thiazolo[5,4-e]indol-7(8H)-one;InSolution?PKRInhibitor;PKRInhibiChemicalbooktor-CAS608512-97-6-CalbiochemCAS号608512-97-6分子式C13H8N4OS分子量268.29EINECS号相关类别活性分子Mol文件608512-97-6.mol结构式8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE性质沸点674.6±55.0°C(Predicted)密度1.604±0.06g/cm3(Predicted)储存条件-20°C溶解度DMSO：可溶，12mg/mL形态橙色至橙棕色固体酸度系数(pKa)10.20±0.20(Predicted)颜色黄色至橙棕色稳定性可在-20°下的DMSO中的溶液储存长达1个月。8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE用途与合成方法生物活性PKR-IN-C16(C16,Imidazolo-oxindolePKRinhibitorC16)是一种RNA-dependentproteinkinase(PKR,ProteinKinaseR,EIF2AK2)的特异性抑制剂。PKR-IN-C16可在具有神经炎症成分的急性兴奋性毒性大鼠模型中阻止凋亡和IL-1β的产生。靶点TargetValuePKR()IL-1β() |
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