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腺苷5'-三磷酸二钠盐水合物 |
CAS No.: |
34369-07-8 |
分子式: |
C10H14N5Na2O13P3路xH2O |
分子量: |
551.14 |
备注: |
中文名称腺苷5’-三磷酸二钠盐水合物中文同义词腺苷-5′-三磷酸二钠盐,(无钙);三磷酸腺苷二钠盐/ATP二钠盐;ADENOSINE5’-TRIPHOSPHATEDISODIUMSALTHYDRATE三磷酸腺苷二钠;5-腺苷三磷酸二钠盐三水物;5-腺苷三磷酸二钠盐水合物;三磷酸腺苷二钠盐水合物;ATP二钠盐水合物;5’-三磷酸腺苷二钠,磷酸腺苷钠英文名称ADENOSINE5’-TRIPHOSPHATEDISODIUMSAL&英文同义词AdenosineImpurity9;-TRIPHOSPHATEDISODIUMSAL&5μ-ATP-Na2,ATPhydratedisodiumsalt;Adenosine-5’-triphosphatedisodiumsalthydrate,99+%(water<10%);Adenosine5’-triphosphate,disodiumsalthydrate,98%;Adenosine-5’-triphosphatedisodiumsalthydrate,water<10%;Adenosine5′-triphosphatedisodiumsalthydrate,5′-ATP-Na2,ATPdisodiumsalthydrate;Adenosine5′-triphosphatedisodiumsalthydrate,ATPdisodiumsaltCAS号34369-07-8分子式C10H19N5NaO14P3分子量549.19EINECS号213-579-1相关类别小分子抑制剂,天然产物;杂环;植物激素及核酸类;医药原料药;含硫化合物;小分子抑制剂;生化试剂;腺苷;核苷,核苷酸,寡核苷酸;生化试剂-植物激素及核酸类;化工原料;中间体-有机中间体;Inhibitors;Pharmaceutical;通用生化试剂-核酸;化学试剂;食品添加剂Mol文件34369-07-8.mol结构式腺苷5’-三磷酸二钠盐水合物性质熔点176°C(dec.)(lit.)储存条件-20°C溶解度在水中的溶解度为50mg/mL,透明,无色形态粉末颜色白色水溶解性Solubleinwater.敏感性LightSensitive&HygroscopicMerck14,155BRN3585462稳定性吸湿性、温度敏感InChIKeyNTBQNWBHIXNPRU-MSQVLRTGSAChemicalbook-LCAS数据库34369-07-8腺苷5’-三磷酸二钠盐水合物用途与合成方法生物活性ATPdisodiumsalthydrate(Adenosine5’-triphosphatedisodiumsalthydrate)是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。ATPdisodiumsalthydrate是免疫和炎症中重要的内源性信号分子。体外研究ATPdisodiumsalthydrate(5mM;1hour)co-treatmentwithLPS(1μg/ml)hasasynergisticeffectontheactivationoftheNLRP3inflammasomeinHGFs.ATPdisodiumsalthydrate(2mM;0.5-24hours)inducessecretionofinterleukin1β,KCandMIP-2frombonemarrowderivedmacrophages(BMDMs)invitroinacaspase-1activation-dependentmanner.ATPdisodiumsalthydratestimulatscytokineandchemokinesecretionandinflammasomeactivationdirectlyandindirectlyinducesinvitroneutrophilchemotaxis.体内研究ATPdisodiumsalthydrate(50mg/kg;i.p.)protectsmiceagainstbacterialinfectioninvivo.ATPdisodiumsalthydrateinducesthesecretionofIL1β,KCandMIP-2andneutrophilsrecruitmentinvivo.AnimalModel:Four-week-oldKunmingmice(18-22g)Dosage:50mg/kgAdministration:Intraperitonealinjection,beforebacterial(E.coli)challengeResult:Protectedmicefrombacterialinfection.用途P2嘌呤能激动剂;增加Ca2+-激活的K+通道活性;依赖ATP的酶底物。 |
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