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2'-脱氧肌苷 |
| CAS No.: |
890-38-0 |
| 分子式： |
C10H12N4O4 |
| 分子量： |
252.23 |
| 备注： |
中文名称2’-脱氧肌苷中文同义词2ˊ-脱氧次黄嘌呤核苷;2ˊ-脱氧肌苷;9-(2-脱氧-Β-D-呋喃核糖基)次黄嘌呤;9-(2-脱氧-Β-D-呋喃核糖)黄嘌呤;2’-脱氧-肌苷水合物;2’-脱氧-肌苷一水合物;9-(2-脱氧-Β-D-呋喃核糖基)次黄嘌呤2’-脱氧次黄嘌呤核苷2’-脱氧肌苷;2’-脱氧肌苷,98+%英文名称2’-Deoxyinosine英文同义词DidanosineEPImpurityC;DidanosineImpurityⅢ:2’-Deoxyinosine;DidanosineImpurity3（DidanosineEPImpurityC）;2’-Deoxyinosine(Di);DEOXYINOSINE,2’-(RG);9-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-9H-purin-6-ol;9-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;1,9-Dihydro-9-(2’-deoxy-β-D-ribofuranosyl)-6H-purin-6-oneCAS号890-38-0分子式C10H12N4O4分子量252.23EINECS号212-964-1相关类别医用原料;核苷;对照品;生化试剂-植物激素及核酸类;生化试剂;核酸;小分子抑制剂;其他生化试剂;化学试剂;植物激素及核酸类;核苷，核苷酸，寡核苷酸;医用原料;PharmaceuticalRawMaterials;Pyridines,Pyrimidines,PurinesandPteredines;Biochemistry;Nucleosidesandtheiranalogs;Nucleosides,Nucleotides&RelatedReagents;Bases&RelatedReagents;Heterocycles;Impurities;Inhibitors;Intermediates&FineChemicals;Nucleotides;Pharmaceuticals;Heterocycles,Impurities,Inhibitors,Nucleotides,Bases&RelatedReagents,Pharmaceuticals,Intermediates&FineChemicals;有机溶剂;对照品;中药对照品;医药原料;通用生化试剂-核酸;2’-脱氧类;有机化工原料Mol文件890-38-0.mol结构式2’-脱氧肌苷性质熔点250°C比旋光度21º(c=1,H2O22ºC)沸点395.4°C(roughestimate)密度1.3402(rouChemicalbookghestimate)折射率-16°(C=1,H2O)储存条件-20°C溶解度DMSO（少许）、水（少许）酸度系数(pKa)8.92±0.70(Predicted)形态粉末颜色白色至类白色水溶解性8.33g/L(25.02ºC)BRN33517InChIInChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1InChIKeyVGONTNSXDCQUGY-RRKCRQDMSA-NSMILESOC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)C[C@@H]1OCAS数据库890-38-0(CASDataBaseReference)NIST化学物质信息Inosine,2’-deoxy-(890-38-0)2’-脱氧肌苷用途与合成方法生物活性2’-deoxyadenosine能够抑制人癌细胞株的生长，并发现其与嘌呤核苷磷酸化酶(PNP)缺乏有关。靶点HumanEndogenousMetabolite体外研究Intheabsenceofdeoxycoformycin,2’-deoxyadenosineisprimarilydeaminatedto2’-deoxyinosineandthenconvertedintohypoxanthine.Inthepresenceoftheinhibitor,thedeoxynucleoside,inadditiontoaphosphorylationprocess,undergoesphosphorolyticcleavagegivingrisetoadenine.Theconversionof2’-deoxyadenosinetoadeninemightrepresentaprotectivedevice,emergingwhentheactivityofadenosinedeaminaseisreducedorinhibited.ThereismuchevidencetoindicatethattheenzymecatalyzingthisprocesssmaybedistinctfrommethylthioadenosinephosphorylaseandS-adenosylhomocysteinehydrolase,whicharetheenzymesreportedtoberesponsiblefortheformationofadeninefrom28-deoxyadenosineinmammals.化学性质白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂。 |
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