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(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚 |
| CAS No.: |
225937-10-0 |
| 分子式： |
C15H16O7 |
| 分子量： |
308.28 |
| 备注： |
中文名称(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚中文同义词(+)-儿茶素(一水物);(2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇一水物;(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚;D(+)-儿茶精;D(+)-儿茶素(四水);D(+)-儿茶酸;反式-3,3ˊ,4ˊ,4,7-五羟基黄烷;四水合-D(+)儿茶素英文名称(+)-CATECHINHYDRATE英文同义词FK-027-13C,15N2;FR-17027-13C,15N2;(+)-Catechinhydrate>=96.0%(suMofenantioMers,HPLC);(2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triolhydrate;2-keto-4-methyl-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylicacidmethylester;4-methyl-2-oxo-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylicacidmethylester;BAS00381104;EU-0067758CAS号225937-10-0分子式C15H16O7分子量308.29EINECS号684-232-3相关类别植提;标准品;分析标准品;植物提取物;植物生化提取物;小分子抑制剂;小分子抑制剂，天然产物;细胞生物;诊断试剂;各种化学试剂;微生物;植物激素及核酸类;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;Inhibitors;生化试剂-植物激素及核酸类;标准品-中药标准品;对照品Mol文件225937-10-0.mol结构式(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚性质熔点175-177°C(anhydrous)(lit.)比旋光度26º(C=1INH2O)储存条件2-8°C溶解度乙醇：可溶50mg/mL形态粉末颜色黄色至黄色带棕褐色旋光性(opticalactivity)[α]/D+26±2°,c=1inH2OMerck13,1912BRN3595244CAS数据库225937-10-0(CASDataBaseReference)(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚用途与合成方法生物活性(+)-Catechinhydrate抑制环加氧酶-1(COX-1),IC50为1.4μM。靶点COX-11.4μM(IC50)体外研究(+)-Catechinexhibits>95%inhibitoryactivityat70μg/mLChemicalbookagainstcyclooxygenase-1(COX-1)withanIC50of1.4μM.Adose-dependentreductionincolorisobservedafter24hoursoftreatmentwith(+)-Catechin,and54.76%ofthecellsaredeadatthehighestconcentrationof(+)-Catechintested(160μg/mL)whereastheIC50of(+)-Catechinisachievedat127.62μg/mL(+)-Catechin.Adose-andtime-dependentincreaseintheinductionofapoptosisisobservedwhenMCF-7cellsaretreatedwith(+)-Catechin.Whencomparetothecontrolcellsat24hours,40.7and41.16%ofthecellstreatedwith150μg/mLand300μg/mL(+)-Catechin,respectively,undergoapoptosis.TheexpressionlevelsofCaspase-3,-8,and-9andp53inMCF-7cellstreatedwith150μg/mL(+)-Catechinfor24hincreaseby5.81,1.42,3.29,and2.68fold,respectively,ascomparetothelevelsinuntreatedcontrolcells.体内研究Animalstreatedwith(+)-Catechinatthelowesttesteddose,i.e.,50mg/kg,p.o.havespentcomparativelymoretimeinexploringthenovelobjectinthechoicetrial,however,thedifferenceisnotstatisticallysignificant.(+)-Catechinpreventsthetime-inducedepisodicmemorydeficitsinadose-dependentmanner,themosteffectivebeing200mg/kg,p.o..Treatmentwith(+)-CatechinpreventstheriseinMPOlevelcomparetoDOXalonetreatmentgroup(21.98±9.44and36.76±4.39%inthehippocampusandthefrontalcortexrespectively).用途黄酮类抗氧剂，来自植物，自由基清道夫，阻止游离自由基对各种生物系统引起的伤害。 |
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