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5-脱氧-5-甲硫腺苷 |
| CAS No.: |
2457-80-9 |
| 分子式： |
C11H15N5O3S |
| 分子量： |
297.33 |
| 备注： |
中文名称5-脱氧-5-甲硫腺苷中文同义词5’-甲硫腺苷;5’-脱氧-5’-硫代甲基酰苷;5-脱氧-5-甲硫腺苷;5ˊ-脱氧-5ˊ-甲硫基腺苷;甲硫腺苷;5′-脱氧-5′-腺苷;5-脱氧-5-甲硫腺苷(5’-脱氧-5’-硫代甲基酰苷、5ˊ-脱氧-5ˊ-甲硫基腺苷);甲硫腺苷对照品英文名称5’-DEOXY-5’-METHYLTHIOADENOSINE英文同义词2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol;7-(5-Methylthio-5-deoxy-D-ribofuranosyl)-7H-purine-6-amine;7-[Tetrahydro-3α,4α-dihydroxy-5β-(methylthiomethyl)furan-2-yl]-7H-purin-6-amine;5’-S-Methyl-5’-thioadesine;5’-Deoxy-5’-(methylthio)adenosine,98%;1-(6-AMino-9H-purin;5’-Deoxy(Methylthio)adenosine;NSC335422CAS号2457-80-9分子式C11H15N5O3S分子量297.33EINECS号相关类别中药对照品;生物碱;化工原料;BiochemicalsandReagents;NucleosideAnalogs;Nucleosides,Nucleotides,OligonucleotidesMol文件2457-80-9.mol结构式5-脱氧-5-甲硫腺苷性质熔点210-213°C(dec.)沸点642.7±65.0°C(Predicted)密度1.85±0.1g/cm3(Predicted)储存条件-20°C溶解度DMF（Chemicalbook少量）、DMSO（少量）、甲醇（少量）酸度系数(pKa)13.10±0.70(Predicted)形态白色固体颜色白色至类白色BRN424205-脱氧-5-甲硫腺苷用途与合成方法简介5-脱氧-5-甲硫腺苷是一种C-5’的羟基被甲硫基（甲硫基）取代的腺苷，可用作抑制剂。生物活性5’-Methylthioadenosine是由S-腺苷酸产生的，有强效的抑制作用。靶点HumanEndogenousMetabolite体外研究5’-Methylthioadenosine(MTA)canaffectcellularprocessesinmanyways.5’-Methylthioadenosinehasbeenshowntoinfluencenumerouscriticalresponsesofthecellincludingregulationofgeneexpression,proliferation,differentiationandapoptosis.Althoughmostoftheseresponseshavebeenobservedatthepharmacologicallevel,theirspecificitymakesittemptingtospeculatethatendogenous5’-Methylthioadenosinecouldplayaregulatoryroleinthecell.Finally,observationscarriedoutinmodelsofliverdamageandcancerdemonstrateatherapeuticpotentialfor5’-Methylthioadenosinethatdeservesfurtherconsideration[1]. |
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