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硫黄素 T |
| CAS No.: |
2390-54-7 |
| 分子式： |
C17H19ClN2S |
| 分子量： |
318.86 |
| 备注： |
中文名称硫黄素T中文同义词2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物;碱性黄1;硫代磺素T;硫代黄色素T;硫黄素T;盐基嫩黄;硫磺素T;硫代黄素T英文名称ThioflavineT英文同义词2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride;Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride;ThioflavineT(C.I.No.49005)forsynthesis;ThioflavinT(Absorbance(E1%1cm)>=750(410nmto414nm,H2O);ThioflavinT*CAS2390-54-7*;avinT;ThiofL;LABOTEST-BBLT00451909CAS号2390-54-7分子式C17H19ClN2S分子量318.86EINECS号219-228-9相关类别色素类;有机硼化合物;生化试剂;化工原料;其他生化试剂;生化试剂-色素类;化学试剂;电镀原材料;功能性添加剂化工原料;电镀添加剂;有机化工原料;通用生化试剂-生物染色剂与化学指示剂;Biochemistry;VitaminDerivatives;Vitamins;化学合成新材料;工业化;酸铜中间体Mol文件2390-54-7.mol结构式硫黄素T性质熔点211-212°C(decomp)密度1.301g/cm3at20℃蒸气压0Paat25℃储存条件Storebelow+30°C.溶解度在甲醇中可溶1mg/mL形态粉末色指数49005颜色黄色至黄褐色BRN3922452LogP3.02at25℃andpH7.98CAS数据库2390-54-7(CASDataBaseReference)EPA化学物质信息Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride(2390-54-7)硫黄素T用途与合成方法生物活性ThioflavinT(ThT,BasicYellow1)是一种苯并噻唑染料，与淀粉样蛋白原纤维结合后显示增强的荧光，通常用于诊断淀粉样蛋白原纤维。体外研究ThioflavinT(ThT)isabenzothiazoledyethatexhibitsenhancedfluorescenceuponbindingtoamylChemicalbookoidfibrilsandiscommonlyusedtodiagnoseamyloidfibrils,bothexvivoandinvitro.Inaqueoussolutions,ThioflavinTisfoundtoexistasmicellesatconcentrationscommonlyusedtomonitorfibrilsbyfluorescenceassay(~10-20μM).SpecificconductivitychangesaremeasuredatvaryingconcentrationofThioflavinTandthecriticalmicellarconcentrationiscalculatedtobe4.0±0.5μM.ChangesinthefluorescenceexcitationandemissionofThioflavinTarealsodependentonthemicelleformation.TheThioflavinTmicellesof3nmdiameteraredirectlyvisualizedusingatomicforcemicroscopy,andboundThioflavinTmicellesareobservedalongthefibrillengthforrepresentativefibrils.IncreasingconcentrationofThioflavinTabovethecriticalmicellarconcentrationshowsincreasednumbersofmicellesboundalongthelengthoftheamyloidfibrils.ThioflavinTmicellesaredisruptedatlowpHasobservedbyatomicforcemicroscopyandfluorescenceenhancementuponbindingofThioflavinTtoamyloidfibrilsalsoreducedbyseveral-foldupondecreasingthepHtobelow3.ThemicellesofThioflavinTbindamyloidfibrilsleadingtoenhancementoffluorescenceemission.用途一种苯并噻唑染料，在与淀粉体连接时可提高荧光效率；用于组织学以及蛋白质表征中 |
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