湖北蝶化新材料科技有限公司

1226-42-2

C16H14O4

270.28

中文名称4,4’-二甲氧基苯酚酯中文同义词4,4’-二甲氧基苯酚酯;P-ANISIL茴香偶酰;茴香偶酰;4,4’-二甲氧基苯偶酰;聯大茴香醯;4,4’-二甲氧基苯酚酯100G;茴香偶酰,98+%;对茴香偶酰英文名称4,4’-DIMETHOXYBENZIL英文同义词p-Anisil,Di-p-anisoyl;4,4’-Dimethoxybenzil,99+%;1,2-Di(4-methoxyphenyl)ethanedione;Bis(4-methoxyphenyl)-1,2-ethanedione;Di(4-methoxyphenyl)diketone;p-Anisil;1,2-Bis(4-methoxyphenyl)-1,2-ethanedione;bis(4-methoxyphenyl)-ethanedionCAS号1226-42-2分子式C16H14O4分子量270.28EINECS号214-960-5相关类别稳定同位素,Others,超干溶剂;聚合引发剂;细胞生物学试剂;药物杂质及中间体;化合物;对照品;AromaticEthers;FunctionalMaterials;PhotopolymerizationInitiatorsMol文件1226-42-2.mol结构式4,4’-二甲氧基苯酚酯性质熔点132-134°C(lit.)沸点373.4°C(rougheChemicalbookstimate)密度1.2117(roughestimate)折射率1.5447(estimate)储存条件Sealedindry,RoomTemperature溶解度DMSO：50mg/mL(184.99mM)；水：<0.1mg/mL（不溶）形态精细结晶粉末颜色粘黄色水溶解性Insolubleinwater.BRN531345CAS数据库1226-42-2(CASDataBaseReference)EPA化学物质信息Anisil(1226-42-2)4,4’-二甲氧基苯酚酯用途与合成方法生物活性4,4’-Dimethoxybenzil是一种人肠胃羧基酯酶(hCECE)抑制剂，Ki为70nM。靶点Ki:70nM(hiCE)体外研究Byreducingirinotecaninduceddiarrhea,hiCEinhibitors(e.g.,4,4’-Dimethoxybenzil,Compound8)canimprovetheanti-cancerefficacyofirinotecan.TofindeffectivehiCEinhibitors,anewvirtualscreeningprotocolthatcombinespharmacophoremodelsderivedfromthehiCEstructureanditsligandshasbeenproposed.