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8-O-乙酰山栀苷甲酯 |
| CAS No.: |
57420-46-9 |
| 分子式： |
C19H28O12 |
| 分子量： |
448.42 |
| 备注： |
中文名称8-O-乙酰山栀苷甲酯中文同义词8-O-ACETYLSHANZHISIDEMETHYLESTER8-O-乙酰山栀苷甲酯;8-O-乙酰山栀苷甲酯(标准品);8-O-乙酰山栀苷甲酯;8-O-乙酰山栀苷甲酯,来源于独一味;8-O-乙酰山栀苷甲酯,>98%;8-O-乙酰山栀苷甲酯(对照品);(1S,4AS,5R,7S,7AS)-7-乙酰氧基-5-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4A,5,6,7,7A-六氢环戊并[C]吡喃-4-羧酸甲酯英文名称8-O-acetylshanzhisidemethylester英文同义词(1S)-1α-(β-D-Glucopyranosyloxy)-5α-hydroxy-7α-acetoxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylicacidmethylester;1α-(β-D-Glucopyranosyloxy)-7α-acetoxy-5α-hydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylicacidmethylester;7α-Acetoxy-1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylicacidmethylester;Barlerin;O-AcetylShanzhisideMethylEster,8-;8-AcetylshanzhisideMethylester;UMbroside;8-O-Acetylshanzhisidemethylester,98%,fromLamiophlomisrotata(Benth.exHook.f.)KudCAS号57420-46-9分子式C19H28O12分子量448.42EINECS号相关类别分析试剂标准品;中药对照品;标准品;植物提取物;对照品;植提标准品;标准品-中药标准品;标准品-对照品;标准品-中药标准品;环烯醚萜;标准品，对照品;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextractMol文件57420-46-9.mol结构式8-O-乙酰山栀苷甲酯性质沸点634.2±55.0°C(Predicted)密度1.52溶解度溶于甲烷形态粉末酸度系数(pKa)12.80±0.70(Predicted)颜色白色8-O-乙酰山栀苷甲酯用途与合成方法生物活性Barlerin(8-O-Acetylshanzhisidemethylester)是从中国西藏民间药用植物中分离出的环孢菌素葡萄糖苷。Barlerin(8-O-AChemicalbookcetylshanzhisidemethylester)可以抑制NF-κB活性。靶点TargetValueNF-κB()体外研究TreatmentofSH-SY5YcellswithBarlerin(8-O-Acetylshanzhisidemethylester)blocksTNF-α-inducednucleartranscriptionfactorκB(NF-κB)activationanddecreaseshigh-mobilitygroupbox-1(HMGB-1)expression..TreatmentofH9c2cellswithBarlerin(8-O-Acetylshanzhisidemethylester)9μMblocksTNF-α-inducedNF-κBphosphorylationbyblockingHigh-mobilitygroupbox1(HMGB1)expression.体内研究Barlerin(8-O-Acetylshanzhisidemethylester)40mg/kgdemonstratessignificantneuroprotectiveeffectevenafterdelayedadministrationat4hrafterI/R.Barlerin40mg/kgattenuatesthehistopathologicaldamage,decreasesbrainswelling,inhibitsNF-κBactivationandreducesHMGB-1expressioninischaemicbraintissue.Barlerin(8-O-Acetylshanzhisidemethylester)significantlypromotesangiogenesisintheischaemicbrainandimprovesfunctionaloutcomeafterstroke.Barlerinalsosignificantlyincreasesvascularizationcomparedwithvehicletreatment.ItincreasestheexpressionofVEGF,Ang1,phosphorylationofTie2andAktVEGF.Barlerin(8-O-Acetylshanzhisidemethylester)significantlyshortenscapillarybloodclottingtimeandreducesbloodlossvolume,butdoesnotinfluencemiceactivatedpartialthromboplastintime,prothrombintimeorthrombintime.Itsignificantlyprolongseuglobulinclotlysistimeinhyperfibrinolysismice.化学性质类白色结晶粉末，易溶于甲醇乙醇，来源于独一味。用途8-O-乙酰山栀苷甲酯具有止血镇痛的作用。用途用于含量测定/鉴定/药理实验等。药理药效:有活化淤血、止痛止血。 |
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