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异樱花亭 |
| CAS No.: |
480-43-3 |
| 分子式： |
C16H14O5 |
| 分子量： |
286.2794 |
| 备注： |
中文名称异樱花亭中文同义词异樱花亭;异樱花亭(异樱花亭苷);异樱花亭(异樱花素);5,7-二羟基-4’-甲氧基黄烷酮;异野樱素;异樱花亭苷;异樱花素;异樱花素,异樱花亭(异樱花亭苷)英文名称ISOSAKURANETIN英文同义词5,7-DIHYDROXY-4’-METHOXYFLAVANONE;ISOSAKURANETIN;(S)-2,3-dihydro-5,7-dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone;ISOSAKURANETIN(P);5,7-DIHYDROXY-4’’-METHOXYFLAVANONEhplc;ISOSAKURANETINWITHHPLC;(2S)-5,7-Dihydroxy-4’-methoxyflavanone;(S)-2,3-Dihydro-2-(4-methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-oneCAS号480-43-3分子式C16H14O5分子量286.28EINECS号207-551-8相关类别对照品标准品;对照品;中药对照品;植物提取物;标准品;分析试剂标准品;对照品-中药对照品;黄酮;标准品-中药标准品;标准品，对照品;Flavanones;FlavonoidsMol文件480-43-3.mol结构式异樱花亭性质熔点193-194°C沸点539.2±50.0°C(Predicted)密度1.370±0.06g/cm3(Predicted)溶解度DMSO：125mg/mL（436.64mM；需要超声波和加热）酸度系数(pKa)7.50±0.40(Predicted)形态粉末颜色白色LogP3.840(est)异樱花亭用途与合成方法产品描述异樱花亭是一种白色针晶(氯仿-甲醇)，溶于氯仿、甲醇、丙酮、乙酸乙酯、DMSO。紫外灯365nm下显绿色荧光，盐酸镁粉反应呈阳性，浓硫酸-香草醛反应显橙红色。生物活性Isosakuranetin是可以在Citrusbergamia的果实中找到的黄烷酮黄酮类化合物。体外研究IsosakuranetinstimulatesmelaChemicalbookninaccumulationinadose-dependentmanner.Inaddition,Isosakuranetinat30μMgraduallyincreasestheexpressionofTyr,TRP1,andTRP2after48and72h.TheMTTassayshowsthatIsosakuranetindecreasesthenumberofcellsatconcentrationsgreaterthan45μM.FurtheranalysisoftrypanbluestainingdemonstratesthatIsosakuranetindoesnotaffecttheviabilityofB16melanocytes,butshowsthatIsosakuranetindecreasestheirproliferationrate.ThetyrosinaseactivityofB16melanocytestreatedwith15and30μMIsosakuranetinfor72hissignificantlyincreasedby2-and3.2-fold,respectively,incomparisonwiththatofthecontrolcells.体内研究Isosakuranetindose-dependentlyincreasesthepaw-withdrawalthresholdwithinthedoserangeof1.5to6mg/kg.PosthocanalysisrevealsthatIsosakuranetinincreasesthepaw-withdrawalthresholdandstatisticalsignificanceisseenattimes30and40minforthedoseof3mg/kgand30to60minforthedoseof6mg/kg.化学性质黄色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于飞机草，蔷薇科樱属植物樱花Prunusserrulata。用途用于含量测定/鉴定/药理实验等。 |
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