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新霉素标液 |
| CAS No.: |
119-04-0 |
| 分子式： |
C23H46N6O13 |
| 分子量： |
614.75 |
| 备注： |
中文名称新霉素标液中文同义词新霉素标液;新霉素溶液;新霉素B;新霉素B六乙酸酯;硫酸弗兰西汀(新霉素B);化合物T15348;新生霉素溶液T1462上海瑞楚;新生霉素溶液T1481上海瑞楚英文名称NEOMYCINB英文同义词Neomycinsolution;neomycinestandardsolution;D-Streptamine,O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy-;NEOMYCINSTANDARD;NEOMYCINB;actilin;actiline;antibiotiqueCAS号119-04-0分子式C23H46N6O13分子量614.64EINECS号204-292-2相关类别原料药API;MechanismofAction;N;L-ZAlphabetic;NA-NIMore...Close...;AminoglycosidesAntibiotics;Antibacterial;Antibiotics;AntibioticsAto;AntibioticsbyApplication;AntibioticsN-SAntibiotics;AntineoplasticandImmunosuppressiveAntibioticsAntibiotics;ChemicalStructureClass;GeneticMarkerSelectionAntibiotics;InterfereswithProteinSynthesisSpectrumofActivityMol文件119-04-0.mol结构式新霉素标液性质熔点>194°C(dec.)沸点658.4°C(roughestimate)密度1.3548(roughestimate)折射率1.6000(estimate)储存条件2-8°C溶解度可溶于酸性水溶液（轻微）、水（轻微）形态液体酸度系数(pKa)12.93±0.70(Predicted)颜色透明的Merck13,6482稳定性吸湿性新霉素标液用途与合成方法生物活性FramyceChemicalbooktin(NeomycinB)是一种氨基糖苷类抗生素，是一种有效的RNaseP裂解活性抑制剂，Ki为35μM。Framycetin竞争RNasePRNA中特定的二价金属离子结合位点。Framycetin抑制锤头状核酶(hammerheadribozyme)，Ki值为13.5μM。Framycetin是5″-azidoneomycinB前体，与miR-525中的Drosha位点结合，可用于肝性脑病和肠致病性大肠杆菌感染。靶点Ki:35μM(RNasePcleavageactivity)and13.5μM(hammerheadribozyme)体外研究TheinhibitionofRNasePRNAcleavagebyFramycetin(NeomycinB;FradiomycinB)issensitivetopHandanincreaseinpHsuppressestheinhibitioninothersystems.Framycetintargetsthebacterialandhumanribosomeandaffecttranslation.5″-azidoneomycinBandFramycetinselectivelyinhibitproductionofthematuremiRNA,boostsadownstreamprotein,andinhibitsinvasioninHCCcellline.FramycetinbindstoastructuralratherthanasequencemotifoftheRNA.Itsprimarycognatetargetisthedecodingsiteofthe16SrRNA,butitalsobindstotheRev-responsiveelementinHIV-1,groupIintrons,andthehammerheadribozyme,andthusinhibitstheirbiologicalfunction.Framycetininducesmisreadingofthegeneticcodeduringtranslationandinhibitsseveralribozymes.Theribosomaltargetsiteisthe16SrRNA1400to1500region. |
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