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衣霉素 |
| CAS No.: |
11089-65-9 |
| 分子式： |
C37H60N4O16 |
| 分子量： |
816.89 |
| 备注： |
中文名称衣霉素中文同义词衣霉素复合物;衣霉素来源于链霉菌属;TUNICAMYCINFROMSTREPTOMYCESSP.来源于链霉菌属;衣霉素(链霉菌属);TUNICAMYCIN衣霉素;链病毒菌素;源于STREPTOMYCESLYSOSUPERFIUSNOV.SP.的链病毒菌素;衣霉素英文名称TUNICAMYCIN英文同义词Aids010655;Aids-010655;Nsc177382;TunicaMycinfroMStreptoMyceslysosuperficus;TunicaMycincoMplex;InSolution?Tunicamycin,;TUNICAMYCIN,STREPTOMYCESIYSOSUPERFICUS;TUNICAMYCIN,STREPTOMYCESLYSOSUPERFICUSCAS号11089-65-9分子式C37H60N4O16分子量816.89EINECS号601-012-4相关类别微生物代谢物;细胞信号和神经生物学;细胞生物学;抗生素;抗生素及抗病毒;抗生素、生物碱;生化试剂;对照品;化合物;化工原料;试剂盒-细胞分析试剂盒;小分子;NucleosidesMore...Close...;Antibacterial;Antibiotics;AntibioticsAto;AntibioticsbyApplication;AntibioticsT-ZAntibiotics;AntifungalAntibiotics;AntineoplasticandImmunosuppressiveAntibioticsAntibiotics;AntiviralAntibiotics;ChemicalStructureClass;InterfereswithProteinSynthesisSpectrumofActivity;L-ZAntibiotics;MechanismofAction;SpectrumofActivity;Signalling;antibioticMol文件11089-65-9.mol结构式衣霉素性质熔点234-235℃(decomposition)比旋光度D20+52°(c=0.5inpyridine)闪点87℃储存条件2-8°C溶解度溶于甲醇、乙醇、DMSO或DMF形态白色至类白色固体颜色白色敏感性Moisture&LightSensitiveBRN6888090稳定性自购买之日起2年内保持稳定。DMSO或乙醇溶液可在-20°C下保存长达1个月。InChIKeyYJQCOFNZVFGCAF-WPChemicalbookTOCQRYSA-NEPA化学物质信息Tunicamycin(11089-65-9)衣霉素用途与合成方法生物活性Tunicamycin是一种同源核苷抗生素的混合物,可抑制N-糖基化并阻断GlcNAc磷酸转移酶(GPT)。Tunicamycin引起细胞内质网(ER)中未折叠蛋白的积累并诱导ER应激，并导致DNA合成受阻和G1期细胞周期停滞。Tunicamycin可抑制革兰氏阳性细菌，酵母，真菌和病毒，并具有抗癌活性。Tunicamycin增加宫颈癌细胞中外泌体的释放。体外研究Tunicamycin(2µg/mL;24hours;CD44+/CD24-andoriginalMCF7cells)treatmentincreasesthesplicedXBP-1,ATF6nucleartranslocationlevelandCHOPproteinexpressioninCD44+/CD24-andoriginalMCF7cells.Tunicamycin-inducedERstresssuppressesCD44+/CD24-phenotypecellsubpopulationandinvitroinvasionandacceleratestumorosphoreformation.UndereffectofTunicamycin,theresultsshowthatinhibitedinvasion,increasedcelldeath,suppressedproliferationandreducedmigrationintheCD44+/CD24-andCD44+/CD24-richMCF7cellculture.WesternBlotAnalysisCellLine:CD44+/CD24-andoriginalMCF7cells[1]Concentration:2µg/mLIncubationTime:24hoursResult:IncreasedlevelofsplicedXBP-1,ATF6nucleartranslocationandCHOPproteinexpressionaredetectedinCD44+/CD24-andoriginalMCF7cells.体内研究Tunicamycin(0.1mg/kgor0.5mg/kg)treatmentdramaticallysuppressestumorgrowthintheCD133+/-MHCC97Lcellsxenograftmodel(BALB/c(nu/nu)mice). |
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