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L-硒代蛋氨酸 |
| CAS No.: |
3211-76-5 |
| 分子式： |
C5H11NO2Se |
| 分子量： |
196.11 |
| 备注： |
中文名称L-硒代蛋氨酸中文同义词L(+)硒代蛋氨酸;L-硒代蛋氨;硒代蛋氨酸;L-(+)-硒代蛋氨酸;硒基-L-甲硫氨酸;(S)-(+)-2-氨基-4-(甲基硒)丁酸;-硒代蛋氨酸;L-SELENOMETHIONINEL-硒代蛋氨酸英文名称L-Selenomethionine英文同义词(S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOICACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRICACID;SEMET;SELENOMETHIONINE,L-(+)-;SELENO-L-METHIONINE;L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOICACID;L-(+)-SELENOMETHIONINE;L-SELENOMETHIONINECAS号3211-76-5分子式C5H11NO2Se分子量196.11EINECS号608-705-0相关类别医药原料药;化学试剂;氨基酸类;细胞信号和神经生物学;食品添加剂;氨基酸;功能性物质-硒代蛋氨酸;对照品;生化试剂-氨基酸类;新材料;化工原料;化工;AminoAcidDerivatives;Methionine[Met,M];AminoAcids;Antioxidant;Biochemistry;Biological-modifiedAminoAcids;ClassesofMetalCompounds;Se(Selenium)Compounds;SemimetalCompounds;SelenoAminoAcid;aminoacid;L-硒代蛋氨酸;原料;医药原料;医用原料;食品添加;优势产品;饲料添加剂;其他;高纯试剂;非天然氨基酸;化学产品;合成材料中间体Mol文件3211-76-5.mol结构式L-硒代蛋氨酸性质熔点265°C比旋光度18º(c=1,1NHCl)沸点320.8±37.0°C(Predicted)折射率18°(C=0.5,2mol/LHCl)储存条件-20°C溶解度H2O:50mg/mL酸度系数(pKa)2.26±0.10(Predicted)形态粉末颜色白色至类白色水溶解性solubleMerck14,8441InChIInChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1InChIKeyRJFAYQIBOAGBLC-BYPYZUCNSA-NSMILESC(O)(=O)[C@@H](N)CC[Se]CLogP0.152(est)CAS数据库3211-76-5(CASDataBaseReference)L-硒代蛋氨酸用途与合成方法生物活性L-SelenoMethionine是Selenomethionine的L-异构体，是硒的主要天然食物形式。L-SelenoMethionine是一种癌症化学预防剂，可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。L-SelenoMethionine还可以增加谷胱甘肽过氧化物酶的表达。靶点HumanEndogenousMetabolite体外研究L-SelenoMethionine(1-500μM;24-72h)isselectivelyinhibitsthegrowthofprostatecancercells,comparedwithnormalcells.L-SelenoMethionine(500μM;48h)induceapoptosisinprostatecancercells.L-SelenoMethionine(500μM;48h)causesanChemicalbookincreaseinarrestintheG2-Mphaseofthecellcycleselectivelyinprostatecancercells.L-SelenoMethionine(5μM;24h)mitigatesgeneexpressionassociatedwiththecellularstressresponsefrom10cGyirradiation.CellViabilityAssayCellLine:Prostatecancercells(LNCaP,PC-3,andDU145)andnormalprostatecells(PrEC,PrSM,andPrSt)Concentration:1,5,10,50,100,500μMIncubationTime:24,48,72hoursResult:Inhibitedthegrowthofprostatecancercells,withalowerIC50(1-90μM)at72hthannormalprostatecells(>500μM).ApoptosisAnalysisCellLine:Prostatecancercells(LNCaP,PC-3,andDU145)andnormalprostatecells(PrEC,PrSM,andPrSt)Concentration:500μMIncubationTime:48hoursResult:ExhibitedthehighestlevelofDNAcondensationinandrogen-responsiveLNCaPcarcinomacells,followedbyPC-3andDU145cells.Exhibitedthenicked-endDNAlabelinginprostatecancercells.PromotedthePARPcleavageinprostatecancercells.CellCycleAnalysisCellLine:Prostatecancercells(LNCaP,PC-3,andDU145)andnormalprostatecells(PrEC,PrSM,andPrSt)Concentration:500μMIncubationTime:48hoursResult:Increasedthesub-G0-G1cellfractionofLNCaP(41.5%),PC-3(12.1%),andDU145cells(11.2%).CausedasignificantincreasesinG2cells,particularlyinLNCaP(13%),PC-3(32%),andDU145(20%)cells.RT-PCRCellLine:Humanthyroidepithelialcells(HTori-3)Concentration:5μMIncubationTime:24hoursResult:DownregulatedtheCDC6,GADD45A,FASandATF3inirradiatedcells.体内研究L-SelenoMethionine(0.06-12μg/gdiet;p.o.for3d)partiallyorcompletelypreventthedecreaseintheserumorplasmalevelsoftotalantioxidantsinratsexposedtogammarays,protonsorHZEparticles.用途可以用于蛋白质的结构分析。拿此产品来饲养细菌，这样最终形成的蛋白质里的特定位置就会被硒所取代，便于结构测定 |
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