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2,5-二羟基苯乙酮 |
| CAS No.: |
490-78-8 |
| 分子式： |
C8H8O3 |
| 分子量： |
152.15 |
| 备注： |
中文名称2,5-二羟基苯乙酮中文同义词2’,5’-二羟基苯乙酮;2,5-二羟基乙酰苯;2,5-二羥苯乙酮;2-乙醯氫醌;2,5-二羟基苯乙酮;2’,5’-二羟基苯乙酮,98+%;苯乙酮,2’,5’-二羟基-;乙酮,1-(2,5-二羟苯基)-英文名称2’,5’-Dihydroxyacetophenone英文同义词1-(2,5-dihydroxyphenyl)-ethanon;1-Acetyl-2,5-dihydroxybenzene;2,5-Dihydroxy-1-acetylbenzene;2’,5’-dihydroxy-acetophenon;Acetophenone,2’,5’-dihydroxy-;Acetylhydroquinone;QUINACETOPHENONE;2-AcetylhydroquinoneQuinacetophenoneCAS号490-78-8分子式C8H8O3分子量152.15EINECS号207-716-4相关类别苯乙酮;通用试剂;有机砌块;羰基化合物;酮;其它酚类;合成材料中间体;对照品;BuildingBlocks;C7toC8;CarbonylCompounds;ChemicalSynthesis;FINEChemical&INTERMEDIATES;AromaticAcetophenones&Derivatives(substituted);Ketones;OrganicBuildingBlocksMol文件490-78-8.mol结构式2,5-二羟基苯乙酮性质熔点204-206°C(lit.)沸点234.6°C(roughestimate)密度1.2143(roughestimate)折射率1.4447(estimate)储存条件Storebelow+30°C.溶解度二恶烷：50mg/mL，透明酸度系数(pKa)9.86±0.18(Predicted)形态晶体或结晶粉末颜色黄色至黄绿色水溶解性insolubleBRN637903InChIKeyWLDWSGZHNBANIO-UHFFFAOYSA-NLogP1.274(est)CAS数据库490-78-8(CASDataBaChemicalbookseReference)NIST化学物质信息Ethanone,1-(2,5-dihydroxyphenyl)-(490-78-8)EPA化学物质信息Ethanone,1-(2,5-dihydroxyphenyl)-(490-78-8)2,5-二羟基苯乙酮用途与合成方法生物活性2’,5’-Dihydroxyacetophenone(DHAP,2-Acetylhydroquinone,Quinacetophenone)是二羟基苯乙酮异构体的混合物，用于食品调味。2’,5’-Dihydroxyacetophenone通过抑制iNOS的表达来显着抑制NO的产生。2’,5’-Dihydroxyacetophenone可通过阻断ERK1/2和NF-κB信号通路来显著地降低促炎细胞因子TNF-α和IL-6的表达水平。靶点TargetValueiNOS()ERK1/2()NF-κB()TNF-α()IL-6()体外研究2,5-DihydroxyacetophenonesignificantlyinhibitsNOproductionviathesuppressionofiNOSexpressionandsignificantlydecreaseslevelsofthepro-inflammatorycytokinesTNF-αandIL-6viathedown-regulationoftheirmRNAexpressioninLPS-stimulatedRAW264.7cells.2,5-Dihydroxyacetophenonepotentlyinhibitsthephosphorylationofextracellularsignal-relatedkinase(ERK)1/2andthenucleartranslocationofnuclearfactor-κB(NF-κB)p65inLPS-stimulatedcells.化学性质淡黄绿色针状结晶。熔点202-203℃。溶于醇，难溶于醚和苯，几乎不溶于冷水。在碱溶液中呈黄色，遇三氧化铁呈蓝色。能升华。用途用于有机合成。生产方法由对苯二酚二乙酸酯在三氯化铝存在下反应而得。 |
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