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4-[4-(N-BOC)哌嗪-1-基]苯基硼酸频哪酯 |
| CAS No.: |
470478-90-1 |
| 分子式： |
C21H33BN2O4 |
| 分子量： |
388.32 |
| 备注： |
中文名称4-[4-(N-BOC)哌嗪-1-基]苯基硼酸频哪酯中文同义词4-(4-BOC-1-哌嗪基)苯硼酸频哪醇酯;4-[4-(N-BOC)哌嗪-1-基]苯基硼酸频哪酯;4-(4-叔丁氧羰基哌嗪)苯硼酸频那醇酯;4-[4-(N-叔丁氧羰基)哌嗪-1-基]苯硼酸频哪醇酯;4-(4-叔丁氧羰基哌嗪基)苯硼酸嚬哪醇酯;4-(4-(N-BOC)哌嗪-1-基)苯基硼酸频哪醇酯;4-(4-(4-(4,4,5,5-四甲基-1,3,2-二氧杂硼烷-2-基)苯基)哌嗪-1-羧酸叔丁酯;4-((4-BOC)哌嗪基)苯硼酸频哪酯英文名称4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONICACID,PINACOLESTER英文同义词TERT-BUTYL4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;4-(4-BOC-PIPERAZINYL)PHENYLBORONICACIDPINACOLESTER;4-Piperazin-1-ylbenzeneboronicacidpinacolester,N4-BOCprotected90%;4(N-TERT-BUTOXYCARBONYLPIPERAZINE)BENZENEBORONICACIDPINACOLESTER;4-Piperazin-1-ylbenzeneboronicacidpinacolester,N4-BOCprotected;Tert-butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-1(2H)-pyrazineChemicalbookcarboxylate;4-[4-(N-Boc)piperazin-1-yl]phenylboronicacidpinacolester;t-butyl4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazinecarboxylateCAS号470478-90-1分子式C21H33BN2O4分子量388.31EINECS号相关类别Aryl;Boronicester;OrganoboronsMol文件470478-90-1.mol结构式4-[4-(N-BOC)哌嗪-1-基]苯基硼酸频哪酯性质熔点157°C沸点501.7±45.0°C(Predicted)密度1.11储存条件Keepindarkplace,Sealedindry,RoomTemperature酸度系数(pKa)3.06±0.10(Predicted)形态固体颜色灰白色至浅黄色InChIKeyZMAVVXGWEHZLDW-UHFFFAOYSA-N4-[4-(N-BOC)哌嗪-1-基]苯基硼酸频哪酯用途与合成方法用途4-(4-Boc-1-哌嗪基)苯硼酸频哪醇酯是Suzuki交叉偶联反应的重要原料，可以与含有a，β不饱和键的羧基化合物进行共轭加成反应，广泛用于医药化工领域。制备以5-溴-2-(4-Boc-哌嗪-1-基)嘧啶为原料、联硼酸频哪醇酯［B2(pin)2］为硼试剂、K3PO4·7H2O为碱，在氯(2-二环己基膦基-2’，4’，6’-三异丙基-1，1’-联苯基)［2-(2’-氨基-1，1’-联苯)］钯(Ⅱ)(Xphos-Pd-G2)和2-二环己基磷-2’，4’，6’-三异丙基联苯(Xphos)体系的催化下合成了4-[4-(N-BOC)哌嗪-1-基]苯基硼酸频哪酯。其合成反应式如下图： |
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