|
|
D-谷氨酰胺 |
| CAS No.: |
5959-95-5 |
| 分子式： |
C5H10N2O3 |
| 分子量： |
146.14 |
| 备注： |
中文名称D-谷氨酰胺中文同义词D-谷氨酰酸;D-氨羰基丁氨酸;D-麸氨酰胺;D-谷氨酸酰胺;D-谷胺酰胺;谷氨酸盐杂质;D-谷氨酸盐;D-谷氨酸-5-酰胺英文名称D-Glutamine英文同义词D(-)-GLUTAMICACID-5-AMIDE;D-GLUTAMICACID5-AMIDE;D-GLUTAMINICACID5-AMIDE;D(-)-GLUTAMINE;D-GLUTAMINE;D-GLUTAMINEextrapure;D-2-Aminoglutaramicacid,D-Glutamicacid5-amide;CitricAcid,Monohydrate,Crystal,ReagentCAS号5959-95-5分子式C5H10N2O3分子量146.14EINECS号673-968-0相关类别细胞信号和神经生物学;膦配体;氨基酸类;化学试剂;中药对照品;对照品;氨基酸;细胞生物学;氨基酸及其衍生物;生化试剂;其他生化试剂;AminoACIDSSERIES;pharmacetical;Glutamine[Gln,Q];AminoAcidsandDerivatives;alpha-AminoAcids;AminoAcids;Biochemistry;AminoAcidsandDerivatives;aminoacid;保护氨基酸;非天然氨基酸;医药中间体、氨基酸衍生物;天然氨基酸极其衍生物;Inhibitors;小分子抑制剂，天然产物;生化试剂-氨基酸类;医用原料;医药原料;D-氨基酸;食品添加剂;杂质对照品;通用生化试剂-氨基酸;chiralMol文件5959-95-5.mol结构式D-谷氨酰胺性质熔点184-185°C比旋光度-32º(589nm,c=10,NHCl)沸点265.74°C(roughestimate)密度1.3394(roughestimate)折射率-33°(C=5,5mol/LHCl)储存条件Keepindarkplace,Inertatmosphere,Roomtemperature溶解度水（轻微，超声处理）酸度系数(pKa)2.27±0.10(Predicted)形态粉末颜色白色水溶解性42.53g/L(temperaturenotstated)BRN1723796InChIKeyZDXPYRJPNDTMRX-GSVOUGTGSA-NLogP-1.576(est)CAS数据库5959-95-5(CASDataBaseReference)D-谷氨酰胺用途与合成方法生物活性D-Glutamine是可渗透细胞的谷氨酰胺(Glutamine)的D型立体异构体。靶点HumanEndogenousMetabolite体外研究GlChemicalbookutamineisakeyaminoacidinthecentralnervoussystem(CNS),playinganimportantroleintheglutamate/GABA-Glutaminecycle(GGC).IntheGGC,Glutamineistransferredfromastrocytestoneurons,whereitwillreplenishtheinhibitoryandexcitatoryneurotransmitterpools.D-Glutaminehasbeenusedtostudyitsroleinconferringprotectionagainstacetaldehyde-induceddisruptionofbarrierfunctioninCaco-2cellmonolayer.RoleofL-Glutamineintheprotectionofintestinalepitheliumfromacetaldehyde-induceddisruptionofbarrierfunctionisevaluatedinCaco-2cellmonolayer.L-Glutaminereducedtheacetaldehyde-induceddecreaseintransepithelilalelectricalresistanceandincreaseinpermeabilitytoinulinandlipopolysaccharideinatime-anddose-dependentmanner;D-Glutamine,L-aspargine,L-arginine,L-lysine,orL-alanineproducednosignificantprotection.D-Glutaminealsofailstoinfluencetheacetaldehyde-induceddecreaseinTERandincreaseininulinflux.D-GlutamineorglutaminaseinhibitorbythemselvesdidnotinfluenceTERorinulinfluxincontroloracetaldehyde-treatedcellmonolayers.LackofeffectofD-GlutamineinprotectionfromacetaldehydeindicatesthattheL-Glutamine-mediatedprotectionisstereospecific.用途是一种药用氨基酸，用于治疗胃和十二指肠溃疡和幼儿智力低下等症，也是治疗白血病药物的中间体。 |
| 结构式： |
 |
 |
|
声明：以上信息未经本网证实,仅供参考,华夏化工网不承担任何风险责任. |
|
