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烟曲霉毒素c |
| CAS No.: |
118974-02-0 |
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中文名称烟曲霉毒素c中文同义词烟曲霉素C,来源于烟曲霉菌;烟曲酶毒素C;烟曲霉震颤素C;烟曲霉毒素C;烟曲霉素C;FUMITROMORGINC英文名称FUMITREMORGINC英文同义词FumitremorginC,Aspergillus.fumigatus-CAS118974-02-0-Calbiochem;FuMitreMorginCFuMitreMorg;(5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1’’,2’’:4’,5’]pyrazino[1’,2’:1,6]pyrido[3,4-b]indole-5,14-dione;12alpha-FumitremorginC;5H,14H-Pyrrolo[1’’,2’’:4’,5’]pyrazino[1’,2’:1,6]pyrido[3,4-b]indole-5,14-dione,1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-,(5aS,12S,14aS)-;FumitremorginC,98%,fromAspergillusfumigatus;12α-FumitremorginC;FumitremorginC,fromAspergillusfumigatusCAS号118974-02-0分子式C22H25N3O3分子量379.45EINECS号相关类别微生物代谢物;抗生素;生化试剂;生物碱;医药原料Mol文件118974-02-0.mol结构式烟曲霉毒素c性质熔点259.5-260.5℃沸点642.9±55.0°C(Predicted)密度1.34±0.1g/cm3(Predicted)储存条件2-8°C溶解度乙腈：可溶5mg/mL酸度系数(pKa)17.16±0.40(Predicted)形态固体颜色白色至浅棕色烟曲霉毒素c用途与合成方法背景烟曲霉毒素是由串珠镰刀菌（Fusariummoniliforme）产生，通常在霉变的玉米中发现，真菌毒素。烟曲霉毒素发现较晚，最早于1988年报告，最常见的是烟曲霉毒素B、烟曲霉毒素C。生物活性FumitremorChemicalbookginC是有效，选择性的ABCG2/BRCP抑制剂。体外研究Multidrugresistance(MDR)isamajorproblemincancerchemotherapy.FumitremorginCisextremelyeffectiveinreversingresistancetomitoxantrone,doxorubicin,andtopotecaninmultidrug-selectedcelllines.InMCF-7/mtxR(amitoxantroneselectedcellline),fumitremorginCreversesmitoxantroneresistance(114-fold)anddoxorubicinresistance(3-fold).FumitremorginC(5/AM)significantlypotentiatesthetoxicityofmitoxantrone(93-fold),doxorubicin(26-fold),andtopotecan(24-fold)inS1M1-3.2cells.Reversalofresistanceisassociatedwithanincreaseindrugaccumulation.FumitremorginCdoesnotreversedrugresistanceincellswithelevatedexpressionofPgporMRP.FumitremorginCalmostcompletelyreversesresistancemediatedbyBCRPinvitroandisapharmacologicalprobefortheexpressionandmolecularactionofthistransporter.FumitremorginCalsoenhancesthetoxicityofmitoxantroneandtopotecaninvector-transfectedMCF-7cells(2.5–5.6fold).ItreducestheIC50oftopotecaninBCRP-overexpressingcellsbelowthatobservedintheuntreatedvector-transfectedcells.. |
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