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雌马酚 |
| CAS No.: |
94105-90-5 |
| 分子式： |
C15H14O3 |
| 分子量： |
242.27 |
| 备注： |
中文名称雌马酚中文同义词纳米脂质体雌马酚;R,S-雌马酚;)-雌马酚;(卤)-EQUOL;(+)-雌马酚;雌马酚,(±)-雌马酚;3-(4-羟基苯基)四氢苯并吡喃-7-醇;雌马酚98%不是S型,混旋的英文名称(+/-)-EQUOL英文同义词7,4’-HoMoisoflavane;NV07α;3-(4-Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol7-Hydroxy-3-(4-hydroxyphenyl)chroman4’,7-Isoflavandiol;3,4-Dihydro-3-(4-hydroxyphenyl)-2H-chromen-7-ol,(+/-)-Equol,4’,7-Isoflavandiol,7-Hydroxy-3-(4-hydroxyphenyl)chroman;4’,7-Isoflavandiol,(+/-)-Equol;4′,7-Dihydroxyisoflavane;(+/-)-Equol(GMP);(±)-EQUOL>=99.0%(TLC)CAS号94105-90-5分子式C15H14O3分子量242.27EINECS号618-999-2相关类别吡喃;医药原料;功能性食品添加;Metabolites;metabolite;Aromatics;Heterocycles;Intermediates&FineChemicals;Metabolites&Impurities;PharmaceuticalsMol文件94105-90-5.mol结构式雌马酚性质熔点158-160?C沸点441.7±45.0°C(Predicted)密度1.286±0.06g/cm3(Predicted)储存条件Inertatmosphere,Storeinfreezer,under-20°C溶解度溶于乙醇形态结晶粉末酸度系数(pKa)9.94±0.40(Predicted)颜色白色至浅黄色至浅红色水溶解性SolubleinDMSOandmethanolor100%ethanol.Insolubleinwater.敏感性HygroscopicBRN87752InChIInChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2InChIKeyADFCQWZHKCXPAJ-UHFFFAOYSA-NSMILESC1OC2=CC(O)=CC=C2CC1C1=CC=C(O)C=C1雌马酚用途与合成方法生物活性(±)-Equol是equol的外消旋体。Equol是大豆异黄酮黄豆苷和大豆黄素的代谢产物。体外研究EquolisfirstisolatedandidChemicalbookentifiedfrompregnant-mares’urineandlaterfoundintheurineofthegoat,cow,henandsheep.Equol,unlikethesoyisoflavonesdaidzeinorgenistein,hasachiralcenterandthereforecanoccuras2distinctdiastereoisomers.S-equolistheexclusiveproductofhumanintestinalbacterialsynthesisfromsoyisoflavonesandbothenantiomersarebioavailable.S-equolhasahighaffinityforestrogenreceptorbeta(Ki=0.73nM),whereasR-equolisrelativelyinactive.EquolcouldpromotetheproliferationanddifferentiationofratosteoblaststhroughactivatingtheER-PKCα-relatedsignalingpathway.Thealkalinephosphataseactivityalsoincreasessignificantlyinalloftheequoland17β-estradiol(E2)groups.Equolalsosignificantlyelevatestheosteocalcinlevels.体内研究Equolisamodestnatriureticandvasorelaxantagentintherat.Orallyadministeredequolisabout8-foldlesspotentthanorallyadministeredfurosemide.Inisolatedaorticringsprecontractedbyadministrationofphenylephrine,administrationofequolrelaxesthecontractedaorta(concentrationforhalf-maximalactivity58.9±16μM).EquolpossessesanticanceractivitythatsuppressestumorformationviaapoptosisinductioninratswithDMBA-inducedmammaryglandtumors.Inaddition,equolshowsahepaticprotectiveeffectbyactingasanantioxidantandbyreducingapoptosis. |
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