湖北蝶化新材料科技有限公司

4673-26-1

C12H8ClI

314.55

中文名称二苯基氯化碘盐中文同义词氯化二亚苯基碘嗡;二亚苯基碘氯化物;二亚苯基碘鎓氯化物;二苯基氯化碘盐;氯化二亚苯基碘鎓;二苯基氯化碘盐(DPI);优选]DIPHENYLENEIODONIUMCHLORIDE;PERFEMIKER]氯化二亚苯基碘鎓,97%英文名称DIPHENYLENEIODONIUMCHLORIDE英文同义词DiphenyleneiodoniumchlorideDibenziodoliumchloride;DiphenyleneiodoniuMchloride,97+%25MG;Dibenz[b,d]iodoliuMChloride;DIBENZIODOLIUMCHLORIDE;DPI;DiphenyleneiodoniumChloride-CAS4673-26-1-Calbiochem;Diphenyleneiodoniumchloride(DPI);DPICHLORIDECAS号4673-26-1分子式C12H8ClI分子量314.55EINECS号251-228-4相关类别生化试剂;酶与辅酶;中药对照品;AllInhibitors;Inhibitors;NitricOxideReagents;NitricOxideMol文件4673-26-1.mol结构式二苯基氯化碘盐性质熔点312-322°C储存条件roomtemp溶解度可溶于DMSO（升温可达5mg/ml）形态粉末颜色米白色稳定性自购买之日起1年内保持稳定。DMSO中的溶液可在-20°C下保存长达2个月。二苯基氯化碘盐用途与合成方法生物活性Diphenyleneiodoniumchloride(DPI)是NADPHoxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。Diphenyleneiodoniumchloride(DPI)还起到TRPA1激活剂的作用，并能选择性地抑制细胞内的活性氧(ROS)。靶点TargetValueNADPHoxidase()体外研究DPI抑制NADPHoxidase、一氧化氮合成酶、黄嘌呤氧化酶和NADPH细胞Chemicalbook色素P450氧化还原酶的活性。飞摩尔级别的DPI即可通过抑制ERK调节的PHOX活性、抑制小胶质细胞的激活，发挥其抗炎活性和神经保护作用。DPI常被用于抑制由多种黄素酶介导的ROS生成。NADPH,NADP+,and2’5’-ADP可阻止DPI的抑制活性。对ARPE-19细胞处理以DPI可引起剂量依赖性和时间依赖性的生长抑制，诱导DNA断裂和促凋亡因子Bax的蛋白水平。除此之外，DPI还可显著地诱导p53的表达和其磷酸化，在DNA损伤或无法修复的DNA周期阻滞中，诱导促凋亡基因的表达。体内研究Intraplantarinjectionof2mMDiphenyleneiodoniumchloridetothehindpawcauseslickingorbitingbehavior.Diphenyleneiodoniumchloridetreatmentimmediatelyor24hafterlipopolysaccharide(LPS)injectionsignificantlyattenuatestheLPS-inducedlossofO4positivecells.TreatmentwithDiphenyleneiodoniumchlorideeitherimmediatelyor24hafterLPSinjectionsignificantlyamelioratestheLPS-induceddisorganizationofthewhitematternervefibers.However,treatmentwithDPI48hafterLPSinjectiondoesnotappeartocorrecttheLPS-inducedwhitematterdamage.DPItreatmenteitherimmediatelyor24hafterLPSinjectionsignificantlyreducestheaccumulationofbothgp91phoxandp67phoxinthemembranefraction.